70720-38-6

Basic information

• Product Name: 2-Pyridinamine, 3-methyl-N-(phenylmethyl)-
• CAS NO: 70720-38-6
• Molecular Formula: C13H14N2
• Molecular Weight: 198.268
• Mol File: 70720-38-6.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 2-Pyridinamine, 3-methyl-N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinamine, 3-methyl-N-(phenylmethyl)-(70720-38-6)
• EPA Substance Registry System: 2-Pyridinamine, 3-methyl-N-(phenylmethyl)-(70720-38-6)

Safety Data

• Hazardous Substances Data: 70720-38-6(Hazardous Substances Data)

Upstream product

• 5123-13-7 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane 
• 36952-37-1 (E)-N-(3-methylpyridin-2-yl)-1-phenylmethanimine 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 138343-75-6 tert-butyl (3-methylpyridin-2-yl)carbamate 
• 100-51-6 benzyl alcohol 
• 108-88-3 toluene 
• 36952-37-1 N-(3-methylpyridin-2-yl)-1-phenylmethanimine 
• 3430-17-9 2-bromo-3-picoline 
• 100-46-9 benzylamine 
• 18368-76-8 2 chloro-3-methylpyridine 

Downstream Products

• 1370412-37-5 N-((3-chlorophenyl)(phenyl)methyl)-3-methylpyridin-2-amine 
• 1370412-43-3 N-((4-chlorophenyl)(phenyl)methyl)-3-methylpyridin-2-amine 
• 1384450-91-2 C₁₉H₁₇⁽²⁾HN₂ 
• 1370412-53-5 C₁₃H₁₃⁽²⁾HN₂ 
• 1370412-39-7 3-methyl-N-(phenyl(p-tolyl)methyl)pyridin-2-amine 
• 1388624-21-2 N-((4-methoxyphenyl)(phenyl)methyl)-3-methylpyridin-2-amine 
• 1370412-51-3 tert-butyl benzhydryl(3-methylpyridin-2-yl)carbamate 
• 21420-61-1 N-(tert-butoxycarbonyl)(diphenylmethyl)amine 
• 1370412-36-4 3-methyl-N-(phenyl(m-tolyl)methyl)pyridin-2-amine 
• 1388624-26-7 C₂₀H₂₀N₂ 
• 1370412-41-1 N-[(4-methoxyphenyl)(phenyl)methyl]-3-methylpyridin-2-amine 
• 1370412-40-0 N-{[4-(tert-butyl)phenyl](phenyl)methyl}-3-methylpyridin-2-amine 

Relevant articles and documents

Copper-catalyzed direct amination of benzylic hydrocarbons and inactive aliphatic alkanes with arylamines

A new synthetic method toward direct C-N bond formation through saturated C-H amination of benzylic hydrocarbons and inactive aliphatic alkanes with primary aromatic amines under an inexpensive catalyst/oxidant (Cu/DTBP) system has been developed. Both aminopyridines and anilines could react smoothly with primary and secondary benzylic C-H substrates or cyclohexane to form the corresponding aromatic secondary amines in moderate to good yields. This protocol has the advantages of wide functional group tolerance and use of readily available raw materials.

Toluene and its Derivatives as Atom-Efficient Benzylating Agents for Secondary Amines

Toluene as a replacement for common N -benzylating agents, such as benzyl bromide, can be an atom-efficient alternative reagent. Under nickel catalysis and mildly oxidative conditions, it is possible to activate toluene efficiently and use it directly for the benzylation of different 2-aminopyridines. The transformation is not restricted to simple toluene, but also substituted derivatives give the desired product in good yields. Effective cleavage of the pyridine moiety is presented.

Rhodium-catalyzed direct alkylation of benzylic amines using alkyl bromides

Within this contribution, the development and substrate scope evaluation of a direct alkylation protocol of the C(sp3)–H bond of benzylic amines using alkyl bromides is reported. This pyridine-directed method is initiated by elimination of the alkyl bromide to a terminal olefin, which is then the true alkylating agent. Graphical abstract: [Figure not available: see fulltext.].