70746-04-2

Basic information

• Product Name: 3,4-dihydroisoquinoline-2(1H)-carboxamide
• Synonyms: 3,4-dihydroisoquinoline-2(1H)-carboxamide
• CAS NO: 70746-04-2
• Molecular Weight: 176.218
• Mol File: 70746-04-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3,4-dihydroisoquinoline-2(1H)-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dihydroisoquinoline-2(1H)-carboxamide(70746-04-2)
• EPA Substance Registry System: 3,4-dihydroisoquinoline-2(1H)-carboxamide(70746-04-2)

Safety Data

• Hazardous Substances Data: 70746-04-2(Hazardous Substances Data)

Upstream product

• 1705-22-2 3,4-dihydro-2(1H)-isoquinolinecarbonitrile 
• 590-28-3 potassium cyanate 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 57-13-6 urea 

Relevant articles and documents

Efficient Synthesis of Benzothiazinone Analogues with Activity against Intracellular Mycobacterium tuberculosis

8-Nitrobenzothiazinones (BTZs) are a promising class of antimycobacterial agents currently under investigation in clinical trials. Starting from thiourea derivatives, a new synthetic pathway to BTZs was established. It allows the formation of the thiazinone ring system in one synthetic step and is applicable for preparation of a wide variety of BTZ analogues. The synthetic procedure furthermore facilitates the replacement of the sulphur atom in the thiazinone ring system by oxygen or nitrogen to afford the analogous benzoxazinone and quinazolinone systems. 36 BTZ analogues were prepared and tested in luminescence-based assays for in vitro activity against Mycobacterium tuberculosis (Mtb) using the microdilution broth method and a high-throughput macrophage infection assay.

Regioselective Formal [3+2] Cycloadditions of Urea Substrates with Activated and Unactivated Olefins for Intermolecular Olefin Aminooxygenation

A new class of intermolecular olefin aminooxygenation reaction is described. This reaction utilizes the classic halonium intermediate as a regio- and stereochemical template to accomplish the selective oxyamination of both activated and unactivated alkenes. Notably, urea chemical feedstock can be directly introduced as the N and O source and a simple iodide salt can be utilized as the catalyst. This formal [3+2] cycloaddition process provides a highly modular entry to a range of useful heterocyclic products with excellent selectivity and functional-group tolerance.