70775-75-6

Basic information

• Product Name: N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride
• Synonyms: N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride;Octenidine hydrochloride;OCTENIDINE DIHYDROCHLORIDE;N,N'-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis(1-octanamine) dihydrochloride;N,N'-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-1-octanaMine Hydrochloride;N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylaMMoniuM) dichloride;ocenidine dihydrochloride;1-OctanaMine,N,N'-(1,10-decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-, hydrochloride (1:2)
• CAS NO: 70775-75-6
• Molecular Formula: C₃₆H₆₂N₄*2ClH
• Molecular Weight: 623.82616
• EINECS: 274-861-8
• Product Categories: Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 70775-75-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 215-217℃
• Boiling Point: 609.3 °C at 760 mmHg
• Flash Point: 322.3 °C
• Appearance: /
• Density: 1.046[at 20℃]
• Vapor Pressure: 0Pa at 25℃
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Soluble in dimethyl sulfoxide and methanol.
• Water Solubility: 14.2g/L at 20℃
• Stability: Hygroscopic
• Merck: 14,6754
• CAS DataBase Reference: N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride(70775-75-6)
• EPA Substance Registry System: N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride(70775-75-6)

Safety Data

• Hazardous Substances Data: 70775-75-6(Hazardous Substances Data)

Usage

Description

N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride, also known as Octenidine dihydrochloride, is a cationic surfactant and bis-(dihydropyridinyl)-decane derivative. It is characterized by its antiseptic properties and is commonly used in the medical and pharmaceutical industries.

Uses

Used in Medical Applications:
N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride is used as an antiseptic for skin, mucous membranes, and wounds. Its cationic surfactant properties allow it to effectively eliminate harmful microorganisms and reduce the risk of infection.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride is utilized for its antiseptic properties, making it a valuable component in the development of various medical products and treatments. Its ability to combat harmful microorganisms contributes to the overall effectiveness and safety of these products.

Flammability and Explosibility

Notclassified

Synthetic route

1,10-bis-(4-chloropyridin-1 (4H)-yl)decane + n-octylamine hydrochloride (142-95-0) → octenidine dihydrochloride (70775-75-6)

Conditions	Yield
In N,N-dimethyl-formamide at 160℃; Inert atmosphere;	94.2%

1,10-dichlorodecane (2162-98-3) + 4-(octylamino)pyridine (64690-19-3) → octenidine dihydrochloride (70775-75-6)

Conditions	Yield
In acetic acid butyl ester for 12h; Reflux;	85.1%
In N,N-dimethyl-formamide at 120 - 180℃;	39%
In water

4-aminopyridine (504-24-5) → octenidine dihydrochloride (70775-75-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen; palladium 10% on activated carbon / ethanol / 80 °C / 2625.26 Torr 2: acetic acid butyl ester / 12 h / Reflux View Scheme

Octanal (124-13-0) → octenidine dihydrochloride (70775-75-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen; palladium 10% on activated carbon / ethanol / 80 °C / 2625.26 Torr 2: acetic acid butyl ester / 12 h / Reflux View Scheme

octenidine dihydrochloride (70775-75-6) → N,N'-(1,10 decanediyldi-1[4H]-pyridinyl-4-ylidene)-bis-(1-octanamine)

Conditions	Yield
With sodium hydroxide In water; toluene at 20 - 30℃;	14.5 g

Upstream product

• 2162-98-3 1,10-dichlorodecane 
• 64690-19-3 4-(octylamino)pyridine 
• 142-95-0 n-octylamine hydrochloride 
• 504-24-5 4-aminopyridine 
• 124-13-0 Octanal 

Relevant articles and documents

PROCESS FOR THE SYNTHESIS OF N-ALKYL-4-PYRIDINAMINES

The present invention relates to an improved process for the synthesis of N-alkyl-4-pyridinamines comprising the catalytic hydrogenation of a precursor compound which is carried out in the presence of an acid.

Process for the preparation of bis(4-amino-1-pyridinium) alkanes

Process for the preparation of bis(4-amino-1-pyridinium)alkanes by reacting difunctionalized alkanes with 4-aminopyridines in water or a mixture of water and organic solvent.