70783-33-4

Basic information

• Product Name: 2,2,2-trifluoro-1-(4-phenoxyphenyl)ethan-1-ol
• Synonyms: 2,2,2-trifluoro-1-(4-phenoxyphenyl)ethan-1-ol
• CAS NO: 70783-33-4
• Molecular Weight: 268.235
• Mol File: 70783-33-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,2,2-trifluoro-1-(4-phenoxyphenyl)ethan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoro-1-(4-phenoxyphenyl)ethan-1-ol(70783-33-4)
• EPA Substance Registry System: 2,2,2-trifluoro-1-(4-phenoxyphenyl)ethan-1-ol(70783-33-4)

Safety Data

• Hazardous Substances Data: 70783-33-4(Hazardous Substances Data)

Upstream product

• 220676-10-8 1-(2,2-difluorovinyl)-4-phenoxybenzene 
• 67-36-7 4-phenoxy benzaldehyde 
• 70783-32-3 2,2,2-trifluoro-1-(4-phenoxyphenyl)-ethanone 

Downstream Products

• 120039-67-0 Toluene-4-sulfonic acid 2,2,2-trifluoro-1-(4-phenoxy-phenyl)-ethyl ester 

Relevant articles and documents

Palladium-Catalyzed Direct Approach to α-Trifluoromethyl Alcohols by Selective Hydroxylfluorination of gem-Difluoroalkenes

A novel palladium-catalyzed selective hydroxylfluorination of gem-difluoroalkenes has been developed. By employing easily obtainable gem-difluoroalkenes and NFSI as the fluorine source, the scope, advantages, and limitations of this reaction were investigated. The reaction presents an efficient synthesis to afford a series of α-trifluoromethyl alcohols in good to excellent yields. Furthermore, this reaction probably proceeds via oxidation of Pd0 to PdII fluoride complex by NFSI, followed by fluoropalladation of gem-difluoroalkenes to generate an α-trifluoromethylbenzyl–Pd intermediate. And this strategy offers more possibilities for the construction of other bonds, such as C–C, C–N and C–S.