70783-48-1

Basic information

• Product Name: 2,2,2-TRIFLUORO-1-FURAN-2-YL-ETHANOL
• Synonyms: 2,2,2-TRIFLUORO-1-(2-FURYL)ETHANOL;2,2,2-TRIFLUORO-1-FURAN-2-YL-ETHANOL
• CAS NO: 70783-48-1
• Molecular Formula: C₆H₅F₃O₂
• Molecular Weight: 166.1
• Mol File: 70783-48-1.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 60°C 12mm
• Flash Point: 41.6 °C
• Appearance: /
• Density: 1.387 g/cm³
• Vapor Pressure: 3.56mmHg at 25°C
• Refractive Index: 1.416
• PKA: 11.31±0.20(Predicted)
• CAS DataBase Reference: 2,2,2-TRIFLUORO-1-FURAN-2-YL-ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-TRIFLUORO-1-FURAN-2-YL-ETHANOL(70783-48-1)
• EPA Substance Registry System: 2,2,2-TRIFLUORO-1-FURAN-2-YL-ETHANOL(70783-48-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 70783-48-1(Hazardous Substances Data)

Usage

General Description

2,2,2-TRIFLUORO-1-FURAN-2-YL-ETHANOL is a chemical compound with the molecular formula C6H5F3O2. It is an organic compound containing a furan ring with a trifluoromethyl group and a hydroxyl group attached to it. 2,2,2-TRIFLUORO-1-FURAN-2-YL-ETHANOL is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential as a solvent or reagent in organic synthesis. 2,2,2-TRIFLUORO-1-FURAN-2-YL-ETHANOL is a colorless liquid with a characteristic odor and is soluble in water and most organic solvents. Due to its functional groups, it has the potential for various applications in the chemical industry.

InChI:InChI=1/C6H5F3O2/c7-6(8,9)5(10)4-2-1-3-11-4/h1-3,5,10H

Upstream product

• 98-01-1 furfural 
• 75-63-8 Bromotrifluoromethane 
• 110-00-9 furan 
• 433-27-2 ethyl trifluoroacetaldehyde hemiacetal 
• 75-46-7 trifluoromethan 
• 55605-84-0 trifluoroacetaldehyde 2,2,2-trifluoroethyl hemiacetal 
• 2314-97-8 iodotrifluoromethane 
• 445476-82-4 N,N-dimethyl-(1-phenyl-2,2,2-trifluoroethoxytrimethylsilyl)-amine 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 340-07-8 N-(trifluoroacetyl)piperidine 

Downstream Products

• 18207-47-1 2-trifluoroacetylfuran 

Relevant articles and documents

Gas/Liquid-Phase Micro-Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N-Sulfinylimines

A micro-flow nucleophilic trifluoromethylation of carbonyl compounds using gaseous fluoroform was developed. This method also allows the first micro-flow transformation of N-sulfinylimines into trifluoromethyl amines with excellent diastereoselectivity. To demonstrate the synthetic utility of this micro-flow synthesis, the formal micro-flow synthesis of Efavirenz is described.

Enantioselective Palladium-Catalyzed [3+2] Cycloaddition of Trimethylenemethane and Fluorinated Ketones

A nitrile-substituted trimethylenemethane (TMM) donor undergoes palladium-catalyzed [3+2] cycloadditions with fluorinated ketones to generate tetrasubstituted trifluoromethylated centers in high enantioselectivity under mild conditions. The generation of the palladium–TMM complex was achieved by a self-deprotonation strategy, which shows remarkable improvements in regiocontrol, efficiency, and atom economy of asymmetric [3+2] cycloadditions. Moreover, the versatility of the nitrile group provides direct access to a variety of synthetically useful intermediates, including amides, aldehydes, and esters. The developed reaction conditions allow for the synthesis of a wide variety of aromatic, heteroaromatic, and aliphatic fluorinated dihydrofurans in excellent regio- and enantioselectivities.

DIRECT TRIFLUOROMETHYLATIONS USING TRIFLUOROMETHANE

A direct trifluoromethylation method preferably using a trifluoromethane as a fluoro-methylating species. In particular, the present method is used for preparing a trifluoromethylated substrate by reacting a fluoromethylatable substrate with a trifiuoromethylating agent in the presence of an alkoxide or metal salt of silazane under conditions sufficient to trifluoromethylate the substrate; wherein the fluoromethylatable substrate includes chlorosilanes, carbonyl compounds such as esters, aryl halides, aldehydes, ketones, chalcones, alkyl formates, alkyl halides, aryl halides, alkyl borates, carbon dioxide or sulfur.