708-53-2 Usage
Uses
1-(2,3-Dihydroxy-4-methoxyphenyl)ethanone is a a neuroprotective compound isolated from Cynenchum paniculatum. It exerts neuroprotective and cognitive-enhancing activities through its antioxidant activity and may be helpful for the treatment of Alzheimer''s disease.
Preparation
Preparation by reaction of acetic acid on pyrogallol 1-methyl ether, ? with zinc chloride at reflux (155–160°) (Nencki reaction); ? with boron trifluoride on a steam bath (77%).
Check Digit Verification of cas no
The CAS Registry Mumber 708-53-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,0 and 8 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 708-53:
(5*7)+(4*0)+(3*8)+(2*5)+(1*3)=72
72 % 10 = 2
So 708-53-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H10O4/c1-5(10)6-3-4-7(13-2)9(12)8(6)11/h3-4,11-12H,1-2H3
708-53-2Relevant articles and documents
Total synthesis of bulbophylol-B
Lin, Jinshun,Zhang, Weige,Jiang, Nan,Niu, Zeyu,Bao, Kai,Zhang, Liang,Liu, Dailin,Pan, Chao,Yao, Xinsheng
experimental part, p. 1938 - 1941 (2009/09/25)
The first total synthesis of bulbophylol-B (1) has been achieved with the longest linear sequence of 12 steps and an overall yield of 17.9% via a new and practical approach to construct the dihydrodibenz[b,f]oxepin skeleton employing Wittig, selective reduction, and intramolecular Ullmann reactions as key steps.
SELECTIVE DEMETHYLATIONS IN 2,3,4-TRIMETHOXYARYL CARBONYL COMPOUNDS
Kaisalo, Leena,Latvala, Anita,Hase, Tapio
, p. 645 - 648 (2007/10/02)
2,3,4-Trimethoxybenzaldehyde, -acetophenone and -benzoic acid give the corresponding 2,3-dihydroxy-4-methoxy compounds in good yield on treatment with BCl3.