708228-53-9Relevant articles and documents
A substituted 1,2-diarylethane from Cymbidium giganteum
Juneja,Sharma,Tandon
, p. 321 - 324 (1985)
In addition to sitosterol and taraxerone, a new substituted 1,2-diarylethane, gigantol has been isolated from Cymbidium giganteum and characterized as 1-(3′-hydroxy-5′-methoxyphenyl-2-(4″-hydroxy-5″-methoxyphenyl)ethane on the basis of physicochemical dat
Styrylheterocycles as a novel class inhibitor of cyclooxygenase-2-mediated prostaglandin E2 production
Lee, Sang Kook,Park, Eun-Jung,Lee, Eunjung,Min, Hye-Young,Kim, Eun-Young,Lee, Taeho,Kim, Sanghee
, p. 2105 - 2108 (2007/10/03)
The inhibitory effects of a series of styrylheterocycles on the production of cyclooxygenase-2-mediated prostaglandin E2 (PGE2) were evaluated in lipopolysaccharide-stimulated RAW264.7 murine macrophages. A new series of potential inhibitors, including 3-[2-(4-methoxy-phenyl)-vinyl]- thiophene, have been identified, thus providing novel chemical leads for the further development of potential inhibitors in this capacity. The suppression of COX-2 mRNA expression by the active styrylheterocycles, in part, was involved in the inhibitory activity against the overproduction of PGE2.