70866-37-4

Basic information

• Product Name: 1,3-Dioxolo[4,5-g]isoquinoline-6(5H)-carboxylic acid, 7,8-dihydro-5-[[2-(hydroxymethyl)-3,4-dimethoxyphenyl]methyl]-, ethyl ester
• CAS NO: 70866-37-4
• Molecular Formula: C23H27NO7
• Molecular Weight: 429.47
• Mol File: 70866-37-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxolo[4,5-g]isoquinoline-6(5H)-carboxylic acid, 7,8-dihydro-5-[[2-(hydroxymethyl)-3,4-dimethoxyphenyl]methyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolo[4,5-g]isoquinoline-6(5H)-carboxylic acid, 7,8-dihydro-5-[[2-(hydroxymethyl)-3,4-dimethoxyphenyl]methyl]-, ethyl ester(70866-37-4)
• EPA Substance Registry System: 1,3-Dioxolo[4,5-g]isoquinoline-6(5H)-carboxylic acid, 7,8-dihydro-5-[[2-(hydroxymethyl)-3,4-dimethoxyphenyl]methyl]-, ethyl ester(70866-37-4)

Safety Data

• Hazardous Substances Data: 70866-37-4(Hazardous Substances Data)

Upstream product

• 29074-38-2 canadine 
• 541-41-3 chloroformic acid ethyl ester 
• 70866-35-2 ethyl 1-(2-chloromethyl-3,4-dimethoxyphenylmethyl)-1,2,3,4-tetrahydro-6,7-methylenedioxyisoquinoline-2-carboxylate 

Downstream Products

• 70866-38-5 1,2,3,4-tetrahydro-1-(2-hydroxymethyl-3,4-dimethoxyphenylmethyl)-2-methyl-6,7-methylenedioxyisoquinoline 
• 76351-81-0 1,2,3,4-tetrahydro-1-(2-hydroxymethyl-3,4-dimethoxyphenylmethyl)-6,7-methylenedioxyisoquinoline 
• 62475-57-4 (+/-)-canadaline 

Relevant articles and documents

Chemical Transformation of Protoberberines. IV. A Novel, Simple Synthesis of (+/-)-Canadaline and a Retroprotoberberine from Tetrahydroberberine

Heating of tetrahydroberberine (1) in ethyl chloroformate preferentially afforded the C8-N bond cleavage (4) with small amounts of the C6-N and C14-N bond cleavage products (5 and 6, respectively).The urethane (4) was effe