70886-33-8

Basic information

• Product Name: 5-NITRO-1,3-BENZOXAZOLE
• Synonyms: 5-NITRO-1,3-BENZOXAZOLE;5-Nitrobenzoxazole
• CAS NO: 70886-33-8
• Molecular Formula: C₇H₄N₂O₃
• Molecular Weight: 164.12
• Mol File: 70886-33-8.mol
• Article Data: 19

Chemical Properties

• Melting Point: 127-129°
• Boiling Point: 294.2°C at 760 mmHg
• Flash Point: 131.7°C
• Appearance: /
• Density: 1.473g/cm³
• Vapor Pressure: 0.0029mmHg at 25°C
• Refractive Index: 1.658
• Storage Temp.: 2-8°C
• PKA: -5.69±0.10(Predicted)
• CAS DataBase Reference: 5-NITRO-1,3-BENZOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-NITRO-1,3-BENZOXAZOLE(70886-33-8)
• EPA Substance Registry System: 5-NITRO-1,3-BENZOXAZOLE(70886-33-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 70886-33-8(Hazardous Substances Data)

Usage

Description

5-NITRO-1,3-BENZOXAZOLE is an organic compound that belongs to the class of benzoxazoles. It is characterized by the presence of a nitro group (-NO2) at the 5th position of the benzoxazole ring. 5-NITRO-1,3-BENZOXAZOLE is known for its chemical reactivity and is widely utilized in various chemical reactions and applications.

Uses

Used in Chemical Synthesis:
5-NITRO-1,3-BENZOXAZOLE is used as a reactant in the copper-catalyzed direct carboxylation of C-H bonds in benzoxazoles and related compounds with carbon dioxide. This reaction is significant in the field of organic chemistry, as it allows for the formation of new carbon-carbon bonds and the synthesis of a wide range of complex molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-NITRO-1,3-BENZOXAZOLE is used as a building block for the synthesis of various drug molecules. Its unique chemical properties make it a valuable component in the development of new drugs with potential therapeutic applications.
Used in Material Science:
5-NITRO-1,3-BENZOXAZOLE is also utilized in the field of material science, particularly in the development of novel materials with specific properties. Its incorporation into polymers and other materials can lead to enhanced performance characteristics, such as improved stability, reactivity, or conductivity.
Used in Dye and Pigment Industry:
5-NITRO-1,3-BENZOXAZOLE is employed in the dye and pigment industry as a colorant or intermediate in the synthesis of various dyes and pigments. Its unique chemical structure contributes to the development of new colors and shades, expanding the range of available options for various applications.
Used in Research and Development:
5-NITRO-1,3-BENZOXAZOLE is a valuable compound in research and development, particularly in the fields of organic chemistry, medicinal chemistry, and materials science. Its unique properties and reactivity make it an essential tool for exploring new chemical reactions, developing new materials, and designing novel drug molecules.

InChI:InChI=1/C7H4N2O3/c10-9(11)5-1-2-7-6(3-5)8-4-12-7/h1-4H

Upstream product

• 273-53-0 benzoxazole 
• 70886-35-0 N-(2-hydroxy-5-nitrophenyl)formamide 
• 99-57-0 2-hydroxy-5-nitroaniline 
• 122-51-0 orthoformic acid triethyl ester 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 70886-35-0 N-(2-hydroxy-5-nitrophenyl)formamide 
• 63837-12-7 1,3-benzoxazole-5-amine 
• 39835-09-1 5-nitro-2-hydroxybenzonitrile 
• 891-43-0 5-nitro-2-phenylbenzo[d]oxazole 
• 1246472-00-3 C₇H₃BrN₂O₃ 
• 112606-69-6 3-(4'-Methyl)phenyl-5-nitro-benzisoxazole 
• 49559-61-7 5-Nitrobenzoxazol-2-carbonsaeuremethylester 
• 49559-67-3 5-nitro-benzooxazole-2-carboxylic acid 
• 1400811-41-7 C₁₅H₈N₂O₃ 
• 7653-47-6 6-nitro-3-phenyl-2H-benzo-[b][1,4]oxazin-2-one 
• 1033-85-8 2-(4'-methoxyphenyl)-5-nitrobenzoxazole 
• 212758-55-9 2-(4-fluorophenyl)-5-nitrobenzo[d]oxazole 
• 962-25-4 2-(4-chlorophenyl)-5-nitrobenzo[d]oxazole 
• 112606-72-1 2-(4-bromophenyl)-5-nitro-1,3-benzoxazole 

Relevant articles and documents

ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE "RIG-I' PATHWAY AND METHODS OF USE THEREOF

The present invention is directed to compounds of Formula (I), which are activators of the RIG-I pathway.

Method for synthesizing benzoxazole through microwave radiation of benzamide compound in water phase

The invention discloses a method for synthesizing benzoxazole through microwave radiation of a benzamide compound in a water phase. The benzamide compound is added into the water phase under the microwave condition to be subjected to a cyclization reaction for generating the benzoxazole under the alkali condition, and the method for preparing the benzoxazole is environmentally friendly, easy and convenient to operate, safe, low in cost and efficient. Compared with the prior art, the method can be applied to a large number of functional groups, the yield is high, the number of by-products is small, and the method is easy to operate, safe, low in cost and environmentally friendly. (Please see the specifications for the formula).

SUBSTITUTED SPIROCYDIC INHIBITORS OF AUTOTAXIN

The present invention relates to compounds according to Formula 1 and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.