709-52-4

Basic information

• Product Name: DL-NORMETANEPHRINE
• Synonyms: DL-NORMETANEPHRINE;DL-3-O-Methylnorepinephrine;DL-m-O-Methylnorepinephrine
• CAS NO: 709-52-4
• Molecular Weight: 0
• Mol File: 709-52-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: DL-NORMETANEPHRINE(CAS DataBase Reference)
• NIST Chemistry Reference: DL-NORMETANEPHRINE(709-52-4)
• EPA Substance Registry System: DL-NORMETANEPHRINE(709-52-4)

Safety Data

• Hazardous Substances Data: 709-52-4(Hazardous Substances Data)

Upstream product

• 60372-07-8 1-(3-methoxy-4-benzyloxyphenyl)-2-nitroethanol 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 121-33-5 vanillin 
• 1435896-51-7 (R)-2-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-2-hydroxyethyl 4-methylbenzenesulfonate 
• 69404-94-0 O-tert-butyldimethylsilylvanillin 
• 1435896-52-8 (R)-2-azido-1-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)ethanol 
• 828269-23-4 (1,1-dimethylethyl)(4-ethenyl-2-methoxyphenoxy)dimethylsilane 
• 1435896-50-6 (R)-1-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)ethane-1,2-diol 
• 1435896-49-3 (S)-1-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)ethane-1,2-diol 

Relevant articles and documents

Lack of enantioselectivity in the SULT1A3-catalyzed sulfoconjugation of normetanephrine enantiomers: An in vitro and computational study

(1R)-Normetanephrine is the natural stereoisomeric substrate for sulfotransferase 1A3 (SULT1A3)-catalyzed sulfonation. Nothing appears known on the enantioselectivity of the reaction despite its potential significance in the metabolism of adrenergic amines and in clinical biochemistry. We confronted the kinetic parameters of the sulfoconjugation of synthetic (1R)-normetanephrine and (1S)-normetanephrine by recombinant human SULT1A3 to a docking model of each normetanephrine enantiomer with SULT1A3 and the 3'-phosphoadenosine-5'- phosphosulfate cofactor on the basis of molecular modeling and molecular dynamics simulations of the stability of the complexes. The KM, Vmax, and kcat values for the sulfonation of (1R)-normetanephrine, (1S)-normetanephrine, and racemic normetanephrine were similar. In silico models were consistent with these findings as they showed that the binding modes of the two enantiomers were almost identical. In conclusion, SULT1A3 is not substrate-enantioselective toward normetanephrine, an unexpected finding explainable by a mutual adaptability between the ligands and SULT1A3 through an "induced-fit model" in the catalytic pocket. Copyright

3-methoxy-4-hydroxyphenylglycol fluorescence polarization immunoassay

The present invention is directed to a fluoroescence polarization immunoassay for determining the 3-methoxy-4-hydroxyphenylglycol content in body fluids, to the various components needed for preparing and carrying out such an assay, and to methods of making these components. Specifically, tracers, immunogens and antibodies are disclosed, as well as methods for preparing them. The assay is conducted by measuring the degree of polarization of plane polarized light that has been passed through a sample containing antiserum and tracer.