709004-41-1

Basic information

• Product Name: 1H-INDOLE-3-CARBOXYLIC ACID, 1-[(4-BROMOPHENYL)METHYL]-, METHYL ESTER
• Synonyms: 1H-INDOLE-3-CARBOXYLIC ACID, 1-[(4-BROMOPHENYL)METHYL]-, METHYL ESTER
• CAS NO: 709004-41-1
• Molecular Formula: C₁₇H₁₄BrNO₂
• Molecular Weight: 344.2
• Mol File: 709004-41-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-INDOLE-3-CARBOXYLIC ACID, 1-[(4-BROMOPHENYL)METHYL]-, METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-INDOLE-3-CARBOXYLIC ACID, 1-[(4-BROMOPHENYL)METHYL]-, METHYL ESTER(709004-41-1)
• EPA Substance Registry System: 1H-INDOLE-3-CARBOXYLIC ACID, 1-[(4-BROMOPHENYL)METHYL]-, METHYL ESTER(709004-41-1)

Safety Data

• Hazardous Substances Data: 709004-41-1(Hazardous Substances Data)

Usage

Molecular structure

A derivative of 1H-indole-3-carboxylic acid with a methyl ester group and a 4-bromophenyl group attached to the indole ring.

Natural occurrence

Found in certain plants.

Chemical classification

A methyl ester derivative.

Potential pharmacological properties

May have potential applications in medicinal chemistry, pharmaceuticals, and drug development.

Biological activity modulation

The 4-bromophenyl group can potentially alter the compound's interactions with biological targets.

Further research needed

Additional investigation is required to fully understand the compound's pharmacological and therapeutic properties.

Upstream product

• 942-24-5 3-methoxycarbonylindole 
• 589-15-1 1-bromomethyl-4-bromobenzene 

Relevant articles and documents

Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors

The B-cell lymphoma-2 (Bcl-2) family proteins are attractive targets for cancer therapy. In our previous work, the structure-activity relationship of WL-276 was studied. According to the results, rhodanine derivatives show potent binding affinity for Bcl-2 and Mcl-1 protein and show weaker activity against Bcl-XLprotein. Based on the previous results, a new class of indole-3-carboxylic acid-based derivatives were designed and synthesized as Bcl-2/Mcl-1 dual inhibitors. Among them, compound 17 has a Kivalue of 0.26?μM for Bcl-2 protein and is better than WL-276. Furthermore, it inhibits the myeloid cell leukemia sequence 1 (Mcl-1) protein with a Kivalue of 72?nM. Especially, compound 31 can selectively acting on Bcl-2 and Mcl-1 protein but not Bcl-XLprotein, which has great significance for developing dual inhibitors targeting Bcl-2 and Mcl-1 protein, as well as specific antitumor abilities in cells.