709031-30-1

Basic information

• Product Name: Hydroxyl-adaMantyl-glycine
• Synonyms: Hydroxyl-adaMantyl-glycine;alpha-Amino-3-hydroxy-tricyclo[3.3.1.1(3,7)]decane-1-acetic acid
• CAS NO: 709031-30-1
• Molecular Formula: C12H19NO3
• Molecular Weight: 225.28416
• Mol File: 709031-30-1.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 401.967 °C at 760 mmHg
• Flash Point: 196.903 °C
• Appearance: /
• Density: 1.409
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.645
• PKA: 2.36±0.10(Predicted)
• CAS DataBase Reference: Hydroxyl-adaMantyl-glycine(CAS DataBase Reference)
• NIST Chemistry Reference: Hydroxyl-adaMantyl-glycine(709031-30-1)
• EPA Substance Registry System: Hydroxyl-adaMantyl-glycine(709031-30-1)

Safety Data

• Hazardous Substances Data: 709031-30-1(Hazardous Substances Data)

Usage

General Description

Hydroxyl-adaMantyl-glycine is a chemical compound with a complex molecular structure. It contains hydroxyl, adamantane, and glycine moieties, which give it unique chemical and physical properties. The presence of the hydroxyl group makes it a highly reactive compound, capable of participating in a variety of chemical reactions. The adamantane moiety provides the molecule with a rigid and stable structure, while the glycine moiety contributes to its solubility and biological activity. Hydroxyl-adaMantyl-glycine has potential applications in medicinal chemistry, drug design, and materials science due to its unique combination of functional groups. Further research and development are needed to fully understand and harness the potential of this compound.

InChI:InChI=1/C12H19NO3/c13-9(10(14)15)11-2-7-1-8(3-11)5-12(16,4-7)6-11/h7-9,16H,1-6,13H2,(H,14,15)

Upstream product

• 709031-28-7 3-hydroxy-α-oxotricyclo [3.3.1.1^3,7]decane-1-acetic acid 
• 420120-31-6 3-hydroxytricyclo[3.3.1.1³'⁷]decane-1-carbaldehyde 
• 1415016-18-0 C₁₉H₂₄N₂O₂S 
• 1415016-19-1 C₁₉H₂₅NO₄S 
• 618-36-0 rac-methylbenzylamine 
• 768-90-1 1-Adamantyl bromide 
• 709031-34-5 dichloro-(tricyclo[3.3.1.1^3,7]decan-1-yl)acetic acid methyl ester 
• 128665-98-5 α-hydroxytricyclo[3.3.1.1^3,7]decane-1-acetic acid methyl ester 
• 709031-35-6 dichloro-(3-hydroxy-adamantan-1-yl)-acetic acid methyl ester 
• 30074-09-0 α-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid 
• 95853-35-3 (S)-(+)-β-amino-1-adamantaneacetic acid 
• 828-51-3 1-Adamantanecarboxylic acid 
• 770-71-8 1-adamantanemethanol 
• 2094-74-8 1-Adamantanecarbaldehyde 

Relevant articles and documents

Synthetic method of saxagliptin intermediate

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthetic method of a saxagliptin intermediate. The intermediate is compound I, compound A2 is taken as a raw material, and compound I is obtained through hydrolysis hydroxylation, hydrogenation and amino protecting reaction. The compound A2 is oxidized by taking 1 - adamantane methanol as a raw material. The resulting compound A2. Due to the fact that the synthetic route is shortened, the production cycle is shortened, and the production cost is greatly reduced. The compound A2 to the compound A3, the hydrolysis and the hydroxylation are synthesized in one step in one step, the amount of waste acid water is greatly reduced, and the optical chiral protecting group is kept off, and the chiral value of the final compound I is greatly improved. The whole reaction process is mild in condition, free of harsh anhydrous anaerobic reaction, greatly reduced in wastewater amount and extremely high in product optical activity.

A process for preparing hydroxy adamantane glycine derivatives

The invention aims to provide a novel and simple synthesis route of a hydroxyadamantylglycine derivative represented by the formula I, namely (aS)-a-[[(1,1-dimethylethoxy)carboxyl]-amino]-1-(3-hydroxyadamantyl)-acetic acid) or salts of the derivative through developing a novel compound. A novel compound namely 2(aS)-a-amino-1-adamantyl-acetamide represented by the formula III is taken as the primary raw material and then is subjected to hydrolysis reactions and hydroxy group introduction so as to obtain the (aS)-a-[[(1,1-dimethylethoxy)carboxyl]-amino]-1-(3-hydroxyadamantyl)-acetic acid) represented by the formula I or salts of the derivative. The invention further provides a synthesis method of the novel compound represented by the formula III. The synthesis method can solve the disadvantages that the cost of enzyme catalyzed reactions is high, the enzyme catalyzed reactions are unstable, the chemical catalysis method has a low ee value, and the reaction product is not easy to purify in the prior art, and thus is more suitable for industrial production.

PROCESS FOR PREPARING DIPEPTIDYL PEPTIDASE IV INHIBITORS AND INTERMEDIATES THEREFOR

A process for preparing an amine of the structure which comprises a. treating an aqueous solution of a keto acid of the structure with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase and/or formate dehydrogenase enzyme (PDH/FDH); and b. adjusting pH of the reaction mixture with sodium hydroxide to form the desired amine which is substantially free of undesirable excess ammonium ions.