70957-27-6Relevant articles and documents
NUCLEIC ACID BASED LADDER COPOLYMERS
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, (2009/01/24)
The present invention relates to a copolymer termed a ladder copolymer because it has two backbones that serve as legs/sides of a ladder structure. These two backbones, one of which is a nucleic acid or nucleic acid-like polymer, are linked together as th
Enantioselective synthesis of (-)-γ-jasmolactone
Missio,Comasseto
, p. 4609 - 4615 (2007/10/03)
The title compound was prepared in seven steps starting from the commercially available 4-ketopimelic acid. The key step features an enantioselective lactonization promoted by PPL.
Lipase-Catalyzed Preparation of Optically Active γ-Butyrolactones in Organic Solvents
Gutman, Arie L.,Zuobi, Kheir,Bravdo, Tamar
, p. 3546 - 3552 (2007/10/02)
Lipases in anhydrous organic solvents catalyze the lactonization of esters of γ-hydroxy carboxylic acids with a high degree of stereospecifity.Under these conditions the lipases exhibit both enantioselectivity and prochiral selectivity.We exploited the enzymes' enantioselectivity for synthesis of chiral lactones from racemic γ-hydroxy esters and their prochiral stereospecifity, i.e. the ability to discriminate between enantiotopic groups of a prochiral molecule, for the enantioconvergent lactonization of symmetrical γ-hydroxy diesters.This approach was used to develop a convenient, high yielding, and stereoselective route to several optically active γ-substituted γ-butyrolactones.
