71-73-8 Usage
Chemical Properties
Yellowish-white, hygroscopic powder.
Uses
Pentothal (Abbott).
Definition
A rapidly acting barbiturate administered
intravenously for general anesthesia and hypnosis.
Commonly known as “truth serum.”
Brand name
Thiopental is BAN.
Hazard
May cause respiratory failure; use onlywith
physician in attendance.
Pharmacokinetics
Thiopental is highly bound to albumin, and free drug availability is increased
in hypoproteinaemia. Protein binding is decreased by alkalaemia,
hyperventilation and some drugs that occupy the same albumin binding
sites, thereby increasing unbound thiopental concentrations. Metabolism
occurs predominantly in the liver, and the metabolites are excreted by the
kidneys. Only a small proportion is excreted unchanged in the urine. The
terminal elimination half-life is approximately 11.5h (longer in the elderly).
Elimination after an infusion is a zero-order process with 10%–15% of the
remaining drug metabolised each hour. Up to 30% of the original dose may
remain in the body at 24h, and a hangover effect is common. Accumulation
may result if further doses of thiopental are administered within 1–2 days.
Safety Profile
Poison by ingestion, intraperitoneal, rectal, subcutaneous, and intravenous routes. Human systemic effects by intraarterial route: acute arterial occlusion; by rectal route: respiratory depression, body temperature decrease, general anesthetic. An experimental teratogen. Experimental reproductive effects. An intravenous anesthetic. When heated to decomposition it emits toxic fumes of NO, and Na2O. See also PENTOTHAL and BARBITURATES
Veterinary Drugs and Treatments
Because of its rapid action and short duration, in young, healthy
animals, thiopental is excellent induction agent (rapid IV bolus)
for general anesthesia with other anesthetics or as the sole anesthetic
agent for very short procedures. In sick or debilitated animals,
thiopental may be used in a more cautious manner (IV, slowly to
effect).
Check Digit Verification of cas no
The CAS Registry Mumber 71-73-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 1 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 71-73:
(4*7)+(3*1)+(2*7)+(1*3)=48
48 % 10 = 8
So 71-73-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H18N2O2S.Na/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15;/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16);/q;+1/p-1
71-73-8Relevant articles and documents
Method for inducing crystalline state transition in medicinal substance
-
, (2008/06/13)
This invention has for its object to provide a method of inducing a transition in crystalline state of a crystallizable medicinal substance with great ease and improved efficiency and uniformity on a high production scale. According to the invention, an extruder is used for inducing a transition from one crystalline state (Δ) to another crystalline state in a crystallizable medicinal substance.
