710-86-1

Basic information

• Product Name: 3-(Hydroxymethyl)-1,3-diazaspiro[4.5]decane-2,4-dione
• Synonyms: 3-(Hydroxymethyl)-1,3-diazaspiro[4.5]decane-2,4-dione
• CAS NO: 710-86-1
• Molecular Formula: C9H14N2O3
• Molecular Weight: 0
• Mol File: 710-86-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.35g/cm³
• Refractive Index: 1.582
• CAS DataBase Reference: 3-(Hydroxymethyl)-1,3-diazaspiro[4.5]decane-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Hydroxymethyl)-1,3-diazaspiro[4.5]decane-2,4-dione(710-86-1)
• EPA Substance Registry System: 3-(Hydroxymethyl)-1,3-diazaspiro[4.5]decane-2,4-dione(710-86-1)

Safety Data

• Hazardous Substances Data: 710-86-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H14N2O3/c12-6-11-7(13)9(10-8(11)14)4-2-1-3-5-9/h12H,1-6H2,(H,10,14)

Upstream product

• 50-00-0 formaldehyd 
• 702-62-5 spiro(imidazolidine-4,1'-cyclohexane)-2,5-dione 

Relevant articles and documents

Spiromustine analogues. Relationships between structure, plasma stability, and antitumor activity

Spiromustine is a hydantoin-containing nitrogen mustard currently in Phase I clinical trial. Since the in vitro plasma half-life of this compound (6.4 min, 37°C, pH 7.4) appeared to be influenced by the hydantoin ring, analogues containing 2-5 methylene spacer groups between this ring and the nitrogen mustard moiety were prepared and evaluated for hydrolytic stability and antitumor activity. Stability correlated with structure and pK(a) values. The proximity of the hydantoin ring to the mustard function was a stabilizing factor. Activity against murine P-388 leukemia was demonstrated and a gradual decrease in this activity was observed as the hydrolytic instability increased. A relationship between analogue structure and a mass spectral rearrangement ion was identified.