71022-85-0

Basic information

• Product Name: 3'-METHOXY[1,1'-BIPHENYL]-2-OL
• Synonyms: AKOS BAR-1746;3'-METHOXY[1,1'-BIPHENYL]-2-OL
• CAS NO: 71022-85-0
• Molecular Formula: C₁₃H₁₂O₂
• Molecular Weight: 200.23
• Mol File: 71022-85-0.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3'-METHOXY[1,1'-BIPHENYL]-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-METHOXY[1,1'-BIPHENYL]-2-OL(71022-85-0)
• EPA Substance Registry System: 3'-METHOXY[1,1'-BIPHENYL]-2-OL(71022-85-0)

Safety Data

• Hazardous Substances Data: 71022-85-0(Hazardous Substances Data)

Usage

Chemical compound

3'-Methoxy[1,1'-biphenyl]-2-ol

Class

Biphenyl compounds

Methoxy group

Attached at the 3' position of one phenyl ring

Hydroxyl group

Attached at the 2 position of the other phenyl ring

Type

Aromatic alcohol

Physical state

Colorless to pale yellow liquid

Applications

Chemical intermediate in the synthesis of pharmaceuticals and organic compounds, research and development

Importance

Understanding reactivity and behavior of similar biphenyl-based compounds in different environments

Upstream product

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Relevant articles and documents

Pd-catalyzed protecting-group-free cross-couplings of iodophenols with atom-economic triarylbismuth reagents

An efficient protocol for the protecting-group-free synthesis of unsymmetrical hydroxybiaryls via the Pd-catalyzed cross-couplings of unprotected iodophenols with triarylbismuth reagents is described. The presented protocols exhibits good to high yields of hydroxybiaryls.

SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS

The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system or method comprising or consisting essentially of a mixture of (a) at least one organosilane and (b) at least one strong base, the definition of strong base now also including hydroxide, especially KOH, said system being preferably, but not necessarily substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate; wherein said system is substantially free of a transition-metal compound.

Suzuki-Miyaura coupling of halophenols and phenol boronic acids: Systematic investigation of positional isomer effects and conclusions for the synthesis of phytoalexins from pyrinae

The Suzuki-Miyaura couplings of o-, m-, and p-halophenols with o-, m-, and p-phenol boronic acids were investigated for all combinations under standardized conditions, using Pd/C as a heterogeneous catalyst and water as a solvent. In the case of iodophenols, conventional heating was used, while for bromophenols significantly better results could be obtained using microwave irradiation. This systematic study revealed that 2,4′-biphenol is particularly difficult to access, irrespective of the starting materials used, but that these difficulties can be overcome by using different additives. The conclusions drawn from this investigation allowed us to identify conditions for the protecting group-free or minimized total synthesis of biaryl-type phytoalexins. These compounds possess antibacterial activity and are produced by fruit trees as a response to microbial infection.