710280-81-2Relevant articles and documents
Monocyclic human tachykinin NK-2 receptor antagonists as evolution of a potent bicyclic antagonist: QSAR and site-directed mutagenesis studies
Giolitti, Alessandro,Altamura, Maria,Bellucci, Francesca,Giannotti, Danilo,Meini, Stefania,Patacchini, Riccardo,Rotondaro, Luigi,Zappitelli, Sabrina,Maggi, Carlo A.
, p. 3418 - 3429 (2007/10/03)
A new series of monocyclic pseudopeptidic tachykinin NK-2 receptor antagonists has been derived from nepadutant with the help of site-directed mutagenesis studies and QSAR models. MEN11558 is the lead compound which is evaluated on a series of 13 new huma