7103-46-0

Basic information

• Product Name: Methanone, cyclohexyl-1-piperidinyl-
• Synonyms: Piperidine, 1-(cyclohexylcarbonyl)-(7CI,8CI,9CI); 1-(Cyclohexanecarbonyl)piperidine; N-Cyclohexanecarbonylpiperidine
• CAS NO: 7103-46-0
• Molecular Formula: C12H21 N O
• Molecular Weight: 195.305
• Mol File: 7103-46-0.mol
• Article Data: 29

Chemical Properties

• CAS DataBase Reference: Methanone, cyclohexyl-1-piperidinyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, cyclohexyl-1-piperidinyl-(7103-46-0)
• EPA Substance Registry System: Methanone, cyclohexyl-1-piperidinyl-(7103-46-0)

Safety Data

• Hazardous Substances Data: 7103-46-0(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 4630-82-4 methyl cyclohexylcarboxylate 
• 98-89-5 Cyclohexanecarboxylic acid 
• 201230-82-2 carbon monoxide 
• 626-62-0 Cyclohexyl iodide 
• 766-05-2 cyclohexane carbonitrile 
• 2591-86-8 N-Formylpiperidine 
• 1431952-61-2 C₁₂H₂₀O₃ 
• 2043-61-0 cyclohexanecarbaldehyde 
• 13939-06-5 molybdenum hexacarbonyl 
• 4441-56-9 cyclohexylboronic acid 

Downstream Products

• 5005-72-1 1-(cyclohexylmethyl)piperidine 
• 121782-18-1 1-((E)-1-Cyclohexyl-propenyl)-piperidine 
• 5005-71-0 N-(cyclohexylmethyl)piperidine hydrochloride 
• 4664-71-5 Cyclohexyl-<3-Chlor-4-dimethylamino-phenyl>-keton 
• 4779-38-8 Cyclohexyl-<4-dimethylamino-phenyl>-keton-N-oxid 
• 175726-15-5 1-(1-chloro-cyclohexylidenemethyl)piperidine 
• 110-89-4 piperidine 
• 2043-61-0 cyclohexanecarbaldehyde 
• 4664-70-4 cyclohexyl(4-(dimethylamino)phenyl)methanone 

Relevant articles and documents

Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds

Targeting the protein-protein interaction (PPI) between nuclear factor erythroid 2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) is a potential therapeutic strategy to control diseases involving oxidative stress. Here, six classes of known small-molecule Keap1-Nrf2 PPI inhibitors were dissected into 77 fragments in a fragment-based deconstruction reconstruction (FBDR) study and tested in four orthogonal assays. This gave 17 fragment hits of which six were shown by X-ray crystallography to bind in the Keap1 Kelch binding pocket. Two hits were merged into compound 8 with a 220-380-fold stronger affinity (Ki = 16 μM) relative to the parent fragments. Systematic optimization resulted in several novel analogues with Ki values of 0.04-0.5 μM, binding modes determined by X-ray crystallography, and enhanced microsomal stability. This demonstrates how FBDR can be used to find new fragment hits, elucidate important ligand-protein interactions, and identify new potent inhibitors of the Keap1-Nrf2 PPI.

IrIII-Catalyzed direct syntheses of amides and esters using nitriles as acid equivalents: A photochemical pathway

An unprecedented IrIII[df(CF3)ppy]2(dtbbpy)PF6-catalyzed simple photochemical process for direct addition of amines and alcohols to the relatively less reactive nitrile triple bond is described herein. Various amides and esters are synthesized as the reaction products, with nitriles being the acid equivalents. A mini-library of different types of amides and esters is made using this mild and efficient process, which uses only 1 mol% of photocatalyst under visible light irradiation (λ = 445 nm). The reaction strategy is also efficient for gram-scale synthesis.

Cross-Dehydrogenating Coupling of Aldehydes with Amines/R-OTBS Ethers by Visible-Light Photoredox Catalysis: Synthesis of Amides, Esters, and Ureas

A straightforward synthesis of amides, ureas, and esters is reported by visible-light cross-dehydrogenating coupling (CDC) of aldehydes (or amine carbaldehydes) and amines/R-OTBS ethers by photoredox catalysis. The reaction is found to be general and high yielding. A plausible mechanistic pathway has been proposed for these transformations and is supported by appropriate controlled experiments.