71095-24-4

Basic information

• Product Name: 1-(2-bromo-5-methoxyphenyl)-1-propanone
• Synonyms: 1-(2-bromo-5-methoxyphenyl)-1-propanone
• CAS NO: 71095-24-4
• Molecular Weight: 243.1
• Mol File: 71095-24-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(2-bromo-5-methoxyphenyl)-1-propanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromo-5-methoxyphenyl)-1-propanone(71095-24-4)
• EPA Substance Registry System: 1-(2-bromo-5-methoxyphenyl)-1-propanone(71095-24-4)

Safety Data

• Hazardous Substances Data: 71095-24-4(Hazardous Substances Data)

Upstream product

• 71095-25-5 1-(2-Brom-5-methoxyphenyl)-propanol 
• 925-90-6 ethylmagnesium bromide 
• 56658-04-9 2-bromo-5-methoxybenzoyl chloride 
• 591-31-1 3-methoxy-benzaldehyde 
• 7507-86-0 2-bromo-5-methoxy-benzaldehyde 

Downstream Products

• 955405-18-2 N-(4-methoxy-6-propioyl-phenyl)-2-thiophenecarboxamide 
• 955405-17-1 N-(4-methoxy-6-propioyl-phenyl)-3-chlorobenzamide 
• 1214272-64-6 1-bromo-2-(1-ethylethenyl)-4-methoxybenzene 
• 1353547-15-5 N-(4-methoxy-2-propionylphenyl)benzamide 
• 1354364-40-1 3-(2-bromo-5-methoxyphenyl)pentan-3-ol 

Relevant articles and documents

A domino palladium-catalyzed C-C and C-O bonds formation via dual O-H bond activation: Synthesis of 6,6-dialkyl-6 H -benzo[ c ]chromenes

An efficient Pd-catalyzed domino reaction of α,α-dialkyl-(2- bromoaryl)methanols to 6,6-dialkyl-6H-benzo[c]chromenes is presented. Their formation can be explained via a five membered Pd(II)-cycle that efficiently involves a domino homocoupling with the second molecule, β-carbon cleavage, and finally intramolecular Buchwald-Hartwig cyclization. This domino process effectively involves breaking of five σ-bonds (2C-Br, 2O-H, and a C-C) and formation of two new σ-bonds (C-C and C-O). This mechanistic pathway is unprecedented and further illustrates the power of transition metal catalysis.