710984-37-5

Basic information

• Product Name: 1-[1,1'-biphenyl]-4-yl-2-[(4-methylphenyl)sulfonyl]-1-ethanone
• Synonyms: 1-[1,1'-biphenyl]-4-yl-2-[(4-methylphenyl)sulfonyl]-1-ethanone
• CAS NO: 710984-37-5
• Molecular Weight: 350.438
• Mol File: 710984-37-5.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 1-[1,1'-biphenyl]-4-yl-2-[(4-methylphenyl)sulfonyl]-1-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[1,1'-biphenyl]-4-yl-2-[(4-methylphenyl)sulfonyl]-1-ethanone(710984-37-5)
• EPA Substance Registry System: 1-[1,1'-biphenyl]-4-yl-2-[(4-methylphenyl)sulfonyl]-1-ethanone(710984-37-5)

Safety Data

• Hazardous Substances Data: 710984-37-5(Hazardous Substances Data)

Upstream product

• 657-84-1 sodium tosylate 
• 135-73-9 2-Bromo-4'-phenylacetophenone 
• 28179-30-8 1‐([1,1'‐biphenyl]‐4‐yl)‐2,2‐dibromoethan‐1‐one 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 75867-42-4 ([1,1'-biphenyl]-4-ylethynyl)trimethylsilane 
• 29079-00-3 4-ethynyl-1,1'-biphenyl 
• 2350-89-2 p-vinylbiphenyl 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 1616562-53-8 4-(1-azidovinyl)-1,1'-biphenyl 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 92-91-1 biphenyl-4-acetaldehyde 
• 34352-84-6 4-(propen-2-yl)biphenyl 

Downstream Products

• 2001-23-2 1-(biphenyl-4-yl)-2-phenylethanone 
• 2562-77-8 2-([1,1′-biphenyl]-4-yl)-1H-benzo[d]imidazole 
• 92-92-2 biphenyl-4-carboxylic acid 

Relevant articles and documents

Copper-Catalyzed Aerobic Oxidative Cleavage of Unstrained Carbon-Carbon Bonds of 1,1-Disubstituted Alkenes with Sulfonyl Hydrazides

Alkoxy radical-mediated carbon-carbon bond cleavages have emerged as a powerful strategy to complement traditional ionic-type transformations. However, carbon-carbon cleavage reaction triggered by alkoxy radical intermediate derived from the combination of alkyl radical and dioxygen, is scarce and underdeveloped. Herein, we report alkoxy radical, which was generated from alkyl radical and dioxygen, mediated selective cleavage of unstrained carbon-carbon bond for the oxysulfonylation of 1,1-disubstituted alkenes, providing facile access to a variety of valuable β-keto sulfones. Mechanistic experiments indicated alkoxy radical intermediate that underwent subsequent regioselective β-scission might be involved in the reaction and preliminary computational studies were conducted to provide a detailed explanation on the regioselectivity of the C—C bond cleavage. Notably, the strategy was successfully applied for constructing uneasily obtained architecturally intriguing molecules.

Dioxygen-Triggered Oxosulfonylation/Sulfonylation of Terminal Olefins toward β-Keto Sulfones/Sulfones

A dioxygen-triggered oxosulfonylation/sulfonylation of unactivated olefins to achieve β-keto sulfones/sulfones has been developed. Interestingly, pluralistic mechanisms were found when different types of compounds were applied as substrates, and different products were achieved. The reaction is carried out with a high atomic efficiency in the absence of a metal and a catalyst at room temperature under an air atmosphere. Importantly, as a proof-of-concept, a bioactive molecule was synthesized on a gram-scale level using this method.

Preparation method of beta-carbonyl sulfone compound

The invention discloses a preparation method of a beta-carbonyl sulfone compound, and belongs to the technical field of organic synthesis. The preparation method of the beta-carbonyl sulfone compoundis provided for solving the problems that in the prior art, operation is complex, the substrate range is narrow, and the functional group tolerance is poor. The preparation method comprises the stepsof taking a compound shown in formula I and a compound shown in formula II as raw materials, taking copper salt as a catalyst, carrying out reaction in an organic solvent, and after the reaction is completed, carrying out aftertreatment to obtain the beta-carbonyl sulfone compound. The preparation method is simple and convenient to operate, mild in reaction condition, wide in substrate range and good in functional group tolerance, the yield reaches up to 93%, and the synthesis cost is remarkably reduced.