711-29-5Relevant articles and documents
Styrene sulfone NLRP3 inflammasome inhibitor, preparation method and application thereof
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Paragraph 0053; 0078-0081; 0090-0091, (2020/10/30)
The invention relates to the field of styrene sulfone compounds and NLRP3 inhibitors, and particularly provides a styrene sulfone NLRP3 inflammasome inhibitor, a preparation method and application thereof, wherein the inhibitor is represented by a formula (1), n is selected from 0 and 1, X is selected from N and O, R1 is selected from different electron withdrawing or electron donating substituents, and R2 is selected from different fat or aromatic substituents. According to the invention, it is verified that the compounds represented by the general formula have NLRP3 inhibitory activity.
Aza vinyl sulfones: Synthesis and evaluation as antiplasmodial agents
Glória, Paulo M.C.,Gut, Jiri,Gonalves, Lídia M.,Rosenthal, Philip J.,Moreira, Rui,Santos, Maria M.M.
body text, p. 7635 - 7642 (2012/01/05)
A series of novel aza vinyl sulfones were designed, synthesized in good yields and evaluated as antiplasmodial agents. Tested compounds did not show activity against papain or the Plasmodium falciparum cysteine protease falcipain-2. However, a number of t
7-Oxanorbornane and norbornane mimics of a distorted β-D- mannopyranoside: Synthesis and evaluation as β-mannosidase inhibitors
Buser, Stephan,Vasella, Andrea
, p. 3151 - 3173 (2007/10/03)
The racemic 7-oxanorbornanyl and norbornanyl aminoalcohols 3, 4, 42, 45, and 46 were synthesized and tested as snail β-mannosidase inhibitors. The amino tetraol 3 was obtained from the known sulfonyl acrylate 9 and furan 10. Esterification provided 11 tha
