711007-46-4

Basic information

• Product Name: 2-(3-formyl-phenyl)-1H-benzoimidazole-4-carboxylic acid amide
• CAS NO: 711007-46-4
• Molecular Weight: 265.271
• Mol File: 711007-46-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3-formyl-phenyl)-1H-benzoimidazole-4-carboxylic acid amide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-formyl-phenyl)-1H-benzoimidazole-4-carboxylic acid amide(711007-46-4)
• EPA Substance Registry System: 2-(3-formyl-phenyl)-1H-benzoimidazole-4-carboxylic acid amide(711007-46-4)

Safety Data

• Hazardous Substances Data: 711007-46-4(Hazardous Substances Data)

Upstream product

• 711007-44-2 2,3-diaminobenzamide 
• 313279-12-8 2-amino-3-nitro-benzamide 
• 711007-45-3 2-(3-[1,3]dioxolan-2-yl-phenyl)-1H-benzoimidazole-4-carboxylic acid amide 

Downstream Products

• 313279-21-9 2-(3-hydroxymethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid amide 

Relevant articles and documents

Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors

The synthesis and biological evaluation of a new series of amine-substituted 2-arylbenzimidazole-4-carboxamide inhibitors of the DNA-repair enzyme poly(ADP-ribose) polymerase-1 (PARP-1) is reported. The introduction of an amine substituent at the 2-aryl position is not detrimental to activity, with most inhibitors exhibiting Ki values for PARP-1 inhibition in the low nanomolar range. Two compounds in this series were found to potentiate the cytotoxicity of the DNA-methylating agent temozolomide by 4-5-fold in a human colorectal cancer cell line.