711022-18-3Relevant articles and documents
DNA binding ligands with improved in vitro and in vivo potency against drug-resistant Staphylococcus aureus
Hu, Wenhao,Bürli, Roland W.,Kaizerman, Jacob A.,Johnson, Kirk W.,Gross, Matthew I.,Iwamoto, Mari,Jones, Peter,Lofland, Denene,Difuntorum, Stacey,Chen, Hsiu,Bozdogan, Bülent,Appelbaum, Peter C.,Moser, Heinz E.
, p. 4352 - 4355 (2007/10/03)
Potent in vivo activity against methicillin-resistant Staphylococcus aureus (MRSA) has been difficult to achieve with previously reported DNA binding antibacterials. Herein, we describe an efficient access to a focused library of new analogues yielding co