71107-23-8

Basic information

• Product Name: 2-(4-methylpyridin-2(1H)-ylidene)-1H-indene-1,3(2H)-dione
• CAS NO: 71107-23-8
• Molecular Formula: C₁₅H₁₁NO₂
• Molecular Weight: 237.2533
• Mol File: 71107-23-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 422.1°C at 760 mmHg
• Flash Point: 174.3°C
• Density: 1.307g/cm³
• Vapor Pressure: 2.48E-07mmHg at 25°C
• Refractive Index: 1.655
• CAS DataBase Reference: 2-(4-methylpyridin-2(1H)-ylidene)-1H-indene-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methylpyridin-2(1H)-ylidene)-1H-indene-1,3(2H)-dione(71107-23-8)
• EPA Substance Registry System: 2-(4-methylpyridin-2(1H)-ylidene)-1H-indene-1,3(2H)-dione(71107-23-8)

Safety Data

• Hazardous Substances Data: 71107-23-8(Hazardous Substances Data)

Usage

Molecular structure

Contains a pyridin-2(1H)-ylidene group and a 1H-indene-1,3(2H)-dione moiety.

Derivative

Of indene and pyridine.

Potential applications

In the pharmaceutical and chemical industries.

Possible use as a pharmacophore

Due to its ability to interact with biological targets.

Versatile intermediate

For the synthesis of other compounds with diverse properties and applications.

Further research and development

Could lead to innovative products and technologies.

Upstream product

• 85-44-9 phthalic anhydride 
• 108-47-4 2,4-lutidine 

Downstream Products

• 80812-94-8 2-<4-methyl-1-(2-piperidinoethyl)-1,2-dihydro-2-pyridylidene>indane-1,3-dione 

Relevant articles and documents

Synthesis and pharmacological evaluation of 2-(2 and 4- pyridinyl)indane-1,3-diones and structuraly related compounds exerting potential anti-inflammatory and antitumoral activities

Our on going work in the series of enamido-diketones issued from 2- azaarylindane-1,3-diones led us to synthesize and experiment N and C2- substituted derivatives of 2-(2 and 4-pyridinyl)indane-1,3-diones as well as of structurally related compounds resulting from the replacement of pyridine by quinoline and benzimidazole. Pharmacological evaluation of their anti- inflammatory activity (by inhibition of carrageenan foot edema) and their anticoagulant activity (by prothombin assay) led to the conclusion of the possibility of achieving a selective antiinflammatory effect. It has been previously established that anticoagulants are liable to exert a protective effect in the development of cancer metastasis. Nevertheless none of the six experimented 2-(pyridin-2-yl)indane-1,3-diones extended survival time of mice treated by P388 lymphocytic leukemia.