71140-70-0 Usage
Description
4-Carboxybutyldiphenylphosphine oxide, also known as 5-(Diphenylphosphinyl)pentanoic Acid, is a chemical compound that is commonly produced as a by-product in the Wittig reaction, a method for olefin synthesis. It has a carboxybutyl group attached to a diphenylphosphine oxide moiety, which gives it unique chemical properties and potential applications in various fields.
Uses
Used in Coordination Polymers:
4-Carboxybutyldiphenylphosphine oxide is used as a ligand in the preparation of praseodymium coordination polymers. The diphenylphosphorylvalerate ligand in these polymers allows for the creation of stable and well-defined structures with potential applications in various areas, such as catalysis, materials science, and medicine.
Used in Prostaglandin Analogs:
4-Carboxybutyldiphenylphosphine oxide is also a by-product in the preparation of prostaglandin analogs. Prostaglandins are bioactive compounds that play important roles in various physiological processes, such as inflammation, pain, and blood clotting. The development of prostaglandin analogs has significant implications in the pharmaceutical industry for the treatment of various diseases and conditions.
Used as a Standard in Analytical Chemistry:
Due to its common production in the Wittig reaction, 4-Carboxybutyldiphenylphosphine oxide can be used as a standard for analyzing products of synthetic routes that utilize this reaction. This allows for accurate determination of the efficiency and selectivity of the reaction, as well as the purity of the synthesized olefins.
Check Digit Verification of cas no
The CAS Registry Mumber 71140-70-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,1,4 and 0 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 71140-70:
(7*7)+(6*1)+(5*1)+(4*4)+(3*0)+(2*7)+(1*0)=90
90 % 10 = 0
So 71140-70-0 is a valid CAS Registry Number.
71140-70-0Relevant articles and documents
Double Wittig reactions with 4-carboxybutylidene triphenylphosphorane as the key step in the synthesis of benzene derivatives metadisubstituted with ωω'-difunctionalized six-carbon chains
Provent, Christophe,Chautemps, Pierre,Gellon, Gisele,Pierre, Jean-Louis
, p. 1393 - 1396 (2007/10/03)
Using a double Wittig reaction from diformylbenzene derivatives, a direct synthetic way to 1,3-di(5-carboxypent-1-yl)benzene compounds is discussed.
Biotin biosynthesis: Preparation of the postulated intermediate thiol
Even, L.,Florentin, D.,Marquet, A.
, p. 758 - 768 (2007/10/02)
Previous work in our group led us to postulate thiol 3 as the first intermediate in the biotransformation of dethiobiotin 1 into biotin 2.A new synthesis of this thiol is described here starting from the lactone 4, an intermediate in the Hofmann La Roche industrial synthesis of biotin.After the failure of the Wittig approach, the side-chain was successfully introduced through a Grignard addition to the lactone followed by reduction of the ketone.Deoxygenation of the xanthate afforded the protected alcohol 29.To obtain the deprotected hydroxy acid 34a it was necessary to oxidize the double bond before the debenzylation of the imidazolidinone ring.The acid 34a was readily transformed into 3.Keywords: biotin / biosynthesis / alcohol deoxygenation / debenzylation
