7116-35-0

Basic information

• Product Name: 3-(3-CHLORO-PHENYL)-PROPIONIC ACID ETHYL ESTER
• Synonyms: 3-(3-CHLORO-PHENYL)-PROPIONIC ACID ETHYL ESTER;Benzenepropanoic acid, 3-chloro-, ethyl ester;3-Chloro-benzenepropanoic acid ethyl ester
• CAS NO: 7116-35-0
• Molecular Formula: C₁₁H₁₃ClO₂
• Molecular Weight: 212.67
• Mol File: 7116-35-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 278°C at 760 mmHg
• Flash Point: 129.1°C
• Appearance: /
• Density: 1.136g/cm³
• Vapor Pressure: 0.00437mmHg at 25°C
• Refractive Index: 1.514
• CAS DataBase Reference: 3-(3-CHLORO-PHENYL)-PROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-CHLORO-PHENYL)-PROPIONIC ACID ETHYL ESTER(7116-35-0)
• EPA Substance Registry System: 3-(3-CHLORO-PHENYL)-PROPIONIC ACID ETHYL ESTER(7116-35-0)

Safety Data

• Hazardous Substances Data: 7116-35-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H13ClO2/c1-2-14-11(13)7-6-9-4-3-5-10(12)8-9/h3-5,8H,2,6-7H2,1H3

Upstream product

• 2373-88-8 ethyl (E)-3-(3-chlorophenyl)prop-2-enoate 
• 2373-88-8 3-(3-chloro-phenyl)-acrylic acid ethyl ester 
• 1866-38-2 3-chlorocinnamic acid 
• 587-04-2 m-Chlorobenzaldehyde 
• 141-78-6 ethyl acetate 
• 620-20-2 1-Chloro-3-chloromethyl-benzene 

Downstream Products

• 22991-03-3 3-(3-chlorophenyl)propanol 
• 63204-32-0 5-(3-chlorobenzyl)-1,2-dihydro-2-thioxo-4(3H)-pyrimidinone 
• 156176-38-4 5-(3-Chloro-benzyl)-1H-pyrimidine-2,4-dione 
• 156176-25-9 Acetic acid 2-[5-(3-chloro-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy]-ethyl ester 
• 1027018-75-2 C₂₉H₂₅ClN₂O₇ 
• 63204-15-9 2-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-5-(3-chlorobenzyl)-4-pyrimidone dihydrochloride 
• 63204-33-1 5-(3-chlorobenzyl)-2-methylthio-4-pyrimidone 
• 22991-04-4 1-Cyan-3-(3-chlor-phenyl)-propan 
• 90347-05-0 1-Chlor-3-<3-chlor-phenyl>-propan 
• 1370228-04-8 1,4-diethyl 2-[(3-chlorophenyl)methyl]-3-oxobutanedioate 
• 21640-48-2 3-chlorohydrocinnamic acid 
• 40478-50-0 3-(3-chlorophenyl)propionyl chloride 
• 42348-86-7 5-chloro-1-indanone 

Relevant articles and documents

Diboron-Mediated Rhodium-Catalysed Transfer Hydrogenation of Alkenes and Carbonyls

A diboron-mediated rhodium-catalysed transfer hydrogenation system using water as the hydrogen donor is developed. In addition to a series of alkenes with good functional group tolerance, this rhodium-based catalytic system also effectively reduces aldehydes and ketones. A plausible mechanism involving the RhI-catalysed hydrogen generation and Rh0-catalysed hydrogenation is proposed for the reaction.

7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS

The compounds of formula (I) are antagonists of the CCR2 receptor Wherein R1-7 and A are as defined in the claims.

Inhibition of uridine phosphorylase: Synthesis and structure-activity relationships of aryl-substituted 5-benzyluracils and 1-[(2- hydroxyethoxy)methyl]-5-benzyluracils

A series of 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils were synthesized and tested for inhibition of murine liver uridine phosphorylase (UrdPase). Inhibitors of UrdPase are reported to enhance the chemotherapeutic utility of 5-fluoro-2'-deoxyuridine and 5-fluorouracil and to ameliorate zidovudine- induced anemia in animal models. We prepared a series of 5-aryl-substituted analogues of 5-benzylacyclouridine (BAU), a good inhibitor of UrdPase (IC50 of 0.46 μM), to develop a compound with enhanced potency and improved pharmacokinetics. The first phase of structure-activity relationship studies on a series of 32 aryl-substituted 5-benzyluracils found several 5-(3- alkoxybenzyl) analogues of 5-benzyluracil with enhanced potency. The acyclovir side chain, the (2-hydroxyethoxy)methyl group, was substituted on the more potent aryl-substituted 5-benzyluracils. The two most potent compounds, 10y (3-propoxy) and 10dd (3-sec-butoxy), were inhibitors of UrdPase with IC50s of 0.047 and 0.027 μM, respectively. Six compounds were tested in vivo for effects on steady-state concentrations of circulating uridine in rats. Plasma uridine levels were elevated 3-9-fold by compound levels that ranged from 8 to 50 μM.