71167-00-5

Basic information

• Product Name: 5-(ethylsulfanyl)pyridin-2-amine
• Synonyms: 5-(ethylsulfanyl)pyridin-2-amine;2-PYRIDINAMINE, 5-(ETHYLTHIO)-;5-(Ethylthio)pyridin-2-amine
• CAS NO: 71167-00-5
• Molecular Formula: C₇H₁₀N₂S
• Molecular Weight: 154.236
• Mol File: 71167-00-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(ethylsulfanyl)pyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(ethylsulfanyl)pyridin-2-amine(71167-00-5)
• EPA Substance Registry System: 5-(ethylsulfanyl)pyridin-2-amine(71167-00-5)

Safety Data

• Hazardous Substances Data: 71167-00-5(Hazardous Substances Data)

Upstream product

• 20511-12-0 2-amino-5-iodopyridine 
• 811-51-8 sodium thioethylate 
• 110-81-6 Diethyl disulfide 
• 183311-60-6 5-bromo-2-(2,2,5,5-tetramethyl-1,2,5-azadisilolidin-1-yl)pyridine 
• 75-08-1 ethanethiol 
• 1072-97-5 5-bromo-2-pyridylamine 

Downstream Products

• 118001-48-2 2-(4-Bromo-phenyl)-6-ethylsulfanyl-imidazo[1,2-a]pyridine 
• 118001-50-6 4-(6-Ethylsulfanyl-imidazo[1,2-a]pyridin-2-yl)-benzaldehyde 
• 118001-49-3 4-(6-Ethylsulfanyl-imidazo[1,2-a]pyridin-2-yl)-benzonitrile 
• 118001-51-7 4-(6-Ethanesulfinyl-imidazo[1,2-a]pyridin-2-yl)-benzaldehyde 
• 118001-52-8 4-(6-Ethanesulfonyl-imidazo[1,2-a]pyridin-2-yl)-benzaldehyde 
• 1360055-23-7 6-tert-butyl-2-{3-[5-(5-(ethanesulfonyl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-(hydroxymethyl)phenyl}-8-fluoro-2H-phthalazin-1-one 
• 1360056-54-7 Acetic acid 2-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-6-[5-(5-ethanesulfonyl-pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl]-benzyl ester 

Relevant articles and documents

Inhibitors of Bruton's Tyrosine Kinase

This application discloses 6-(2-Hydroxymethyl-phenyl)-2-methyl-2H-pyridazin-3-one derivatives according to generic Formula I: wherein, variables X, R, and Y4, are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation, such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

BETA-AMYLOID PET IMAGING AGENTS

Novel derivatives of imidazopyridinylbenzeneamines and novel derivatives of benzothiazolylbenzeneamines are disclosed that offer improved behavior when used as imaging agents for positron emission tomography of beta-amyloids. Also disclosed is a palladium-catalyzed reaction scheme under microwave conditions for aryl thioethers in general that provides a high ratio of substitution relative to reduction and can be used for the imidazopyridinylbenzeneamine derivatives as well as other compounds of related structure.

Titanium(IV) chloride promoted syntheses of new imidazo[1,2-a]pyridine derivatives under microwave conditions

A new method is described for the synthesis of imidazo[1,2-a]pyridine derivatives from the reaction of 2-aminopyridines with α-haloketones. The critical reagent is titanium(IV) chloride, which appears to serve as a strong dehydrating agent to promote formation of putative Schiff base intermediates, which cyclize subsequently to form the products. The reactions were performed rapidly under microwave conditions. Multiple reaction conditions were evaluated, including reaction temperature, solvent and other Lewis acids. Various combinations of substitution patterns in both the α-haloketone and 2-aminopyridine substrates were examined to evaluate the scope of the reaction. The reaction is quite sensitive to substituents in both substrates, especially those with basicity or coordination ability. Georg Thieme Verlag Stuttgart.