71193-36-7

Basic information

• Product Name: 2-CHLORO-1,2-BIS-(4-METHOXY-PHENYL)-ETHANONE
• Synonyms: 1,2-Bis(4-methoxyphenyl)-2-chloroethanone
• CAS NO: 71193-36-7
• Molecular Formula: C₁₆H₁₅ClO₃
• Molecular Weight: 290.74
• Mol File: 71193-36-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 443.6°C at 760 mmHg
• Flash Point: 176.4°C
• Appearance: /
• Density: 1.202g/cm³
• Vapor Pressure: 4.56E-08mmHg at 25°C
• Refractive Index: 1.566
• CAS DataBase Reference: 2-CHLORO-1,2-BIS-(4-METHOXY-PHENYL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-1,2-BIS-(4-METHOXY-PHENYL)-ETHANONE(71193-36-7)
• EPA Substance Registry System: 2-CHLORO-1,2-BIS-(4-METHOXY-PHENYL)-ETHANONE(71193-36-7)

Safety Data

• Hazardous Substances Data: 71193-36-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H15ClO3/c1-19-13-7-3-11(4-8-13)15(17)16(18)12-5-9-14(20-2)10-6-12/h3-10,15H,1-2H3/t15-/m1/s1

Upstream product

• 119-52-8 4,4'-dimethoxybenzoin 
• 7719-09-7 thionyl chloride 
• 7719-12-2 phosphorus trichloride 
• 75-62-7 Bromotrichloromethane 
• 123-11-5 4-methoxy-benzaldehyde 
• 120-44-5 1,4-di(4-methoxyphenyl)ethanone 

Downstream Products

• 855742-83-5 3-(4,4'-dimethoxy-benzhydryl)-pentan-3-ol 
• 39090-33-0 2,3-bis(p-methoxyphenyl)oxirane 
• 10409-53-7 phosphoric acid 1,2-diphenyl-vinyl ester diethyl ester 
• 65564-55-8 2-methoxy-1,2-bis(4-methoxyphenyl)ethan-1-one 
• 102591-90-2 2,3-bis-(4-methoxy-phenyl)-5-methyl-benzofuran 
• 119-52-8 4,4'-dimethoxybenzoin 
• 119525-60-9 1,2-bis-(4-methoxyphenyl)-2-(4'-methylphenoxy)ethanone 
• 130717-61-2 4,5-bis(4-methoxyphenyl)thiazole-2-carboxylic acid ethyl ester 
• 130717-68-9 2-((acetylamino)methyl)-4,5-bis(4-methoxyphenyl)thiazole 
• 17358-77-9 2,3-bis(4-methoxyphenyl)naphtho[1,2-b]furan 
• 119525-66-5 2-(4-Hydroxy-naphthalen-1-yl)-1,2-bis-(4-methoxy-phenyl)-ethanone 
• 130735-43-2 4,5-bis(4-methoxyphenyl)-2-(4-pyridyl)thiazole 
• 27895-99-4 1,2-Bis-(4-methoxy-phenyl)-2-p-tolylsulfanyl-ethanone 
• 121905-31-5 1,2-Bis-(4-methoxy-phenyl)-2-(4-nitro-phenylsulfanyl)-ethanone 

Relevant articles and documents

Cu-Catalyzed Site-Selective Benzylic Chlorination Enabling Net C–H Coupling with Oxidatively Sensitive Nucleophiles

Site-selective chlorination of benzylic C–H bonds is achieved using a CuICl/bis(oxazoline) catalyst with N-fluorobenzenesulfonimide as the oxidant and KCl as a chloride source. This method exhibits higher benzylic selectivity, relative to estab

Design and synthesis of imidazo[2,1-b]thiazole-chalcone conjugates: Microtubule-destabilizing agents

A series of chalcone conjugates featuring the imidazo[2,1- b]thiazole scaffold was designed, synthesized, and evaluated for their cytotoxic activity against five human cancer cell lines (MCF-7, A549, HeLa, DU-145 and HT-29). These new hybrid molecules have shown promising cytotoxic activity with IC50 values ranging from 0.64 to 30.9 mm. Among them, (E)-3-(6-(4- fluorophenyl)-2,3-bis(4-methoxyphenyl)imidazo[2,1-b]thiazol-5- yl)-1-(pyridin-2-yl)prop-2-en-1-one (11 x) showed potent antiproliferative activity with IC50 values ranging from 0.64 to 1.44 mm in all tested cell lines. To investigate the mechanism of action, the detailed biological aspects of this promising conjugate (11x) were carried out on the A549 lung cancer cell line. The tubulin polymerization assay and immunofluoresence analysis results suggest that this conjugate effectively inhibits microtubule assembly in A549 cells. Flow cytometric analysis revealed that this conjugate induces cell-cycle arrest in the G2/M phase and leads to apoptotic cell death. This was further confirmed by Hoechst staining, activation of caspase-3, DNA fragmentation analysis, and Annexin V-FITC assay. Moreover, molecular docking studies indicated that this conjugate (11 x) interacts and binds efficiently with the tubulin protein.

Utilization of natural sunlight and air in the aerobic oxidation of benzyl halides

Chemical equations presented. A novel, efficient oxidation of α-aryl halogen derivatives to the corresponding α-aryl carbonyl compounds at room temperature has been disclosed. Natural sunlight and air are successfully utilized in this approach through the combination of photocatalysis and organocatalysis. A plausible mechanism was proposed on the basis of the mechanistic studies.