7123-49-1

Basic information

• Product Name: 4-chloro-2-[(phenylamino)methyl]phenol
• Synonyms: 4-chloro-2-[(phenylamino)methyl]phenol;UKRORGSYN-BB BBV-118797
• CAS NO: 7123-49-1
• Molecular Formula: C₁₃H₁₂ClNO
• Molecular Weight: 233.69
• Mol File: 7123-49-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-chloro-2-[(phenylamino)methyl]phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2-[(phenylamino)methyl]phenol(7123-49-1)
• EPA Substance Registry System: 4-chloro-2-[(phenylamino)methyl]phenol(7123-49-1)

Safety Data

• Hazardous Substances Data: 7123-49-1(Hazardous Substances Data)

Upstream product

• 15501-17-4 5-chlorosalicylideneaniline 
• 51892-04-7 3,4-dihydro-3-phenyl-6-chloro-2H-1,3-benzoxazine 
• 50-00-0 formaldehyd 
• 106-48-9 4-chloro-phenol 
• 62-53-3 aniline 

Downstream Products

• 51892-04-7 3,4-dihydro-3-phenyl-6-chloro-2H-1,3-benzoxazine 
• 7082-55-5 7-chloro-4-phenyl-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine 

Relevant articles and documents

Influence of substituent on equilibrium of benzoxazine synthesis from Mannich base and formaldehyde

N-Substituted aminomethylphenol (Mannich base) and 3,4-dihydro-2H-3- substituted 1,3-benzoxazine (benzoxazine) were synthesized from substituted phenol (p-cresol, phenol, p-chlorophenol), substituted aniline (p-toluidine, aniline, p-chloroaniline) and formaldehyde to study influence of substituent on equilibrium of benzoxazine synthesis from Mannich base and formaldehyde. 1H-NMR and charges of nitrogen and oxygen atoms illustrate effect of substituent on reactivity of Mannich base, while oxazine ring stability is characterized by differential scanning calorimetry (DSC) and C-O bond order. Equilibrium constants were tested from 50 °C to 80 °C, and the results show that substituent attached to phenol or aniline has same impact on reactivity of Mannich base; however, it has opposite influence on oxazine ring stability and equilibrium constant. Compared with the phenol-aniline system, electron-donating methyl on phenol or aniline increases the charge of nitrogen and oxygen atoms in Mannich base. When the methyl group is located at para position of phenol, oxazine ring stability increases, and the equilibrium constant climbs, whereas when the methyl group is located at the para position of aniline, oxazine ring stability decreases, the benzoxazine hydrolysis tends to happen and equilibrium constant is significantly low. the Partner Organisations 2014.