712301-24-1Relevant articles and documents
Complexes
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Page/Page column 58; 80; 81, (2017/10/24)
A palladium(II) complex of formula (1) or a palladium(II) complex of formula (3). Also, processes for the preparation of the complexes, and their use in carbon-carbon and carbon-heteroatom coupling reactions.
Scaffold hopping approach to a new series of smoothened antagonists
Lu, Wenfeng,Geng, Delong,Sun, Zhijian,Yang, Zhaohui,Ma, Haikuo,Zheng, Jiyue,Zhang, Xiaohu
, p. 2300 - 2304 (2014/05/20)
The hedgehog (Hh) signaling pathway is a key regulator during embryonic development, while in adults, it has limited functions such as stem cell maintenance and tissue repair. The aberrant activity of the Hh signaling in adults has been linked to numerous human cancers. Inhibition of Hh signaling therefore represents a promising approach toward novel anticancer therapies. The Smoothened (Smo) receptor mediates Hh signaling. Here we report a new series of Smo antagonists which were obtained by a scaffold hopping strategy. Compounds from this new scaffold demonstrated decent inhibition of Hh pathway signaling. The new scaffold can serve as a starting point for further optimization.
Copper-mediated n-heteroarylation of primary sulfonamides: Synthesis of mono-n-heteroaryl sulfonamides
Baffoe, Jonathan,Hoe, Madelene Y.,Barry Tou Re
supporting information; experimental part, p. 1532 - 1535 (2010/06/19)
"Figure Presented" We describe the coupling of primary sulfonamides and various halogenated heterocyclic cores, with an emphasis on 2-heteroaryl halides, via copper catalysis. These studies enabled the synthesis of many new mono-N-heteroaryl sulfonamides.
