71231-25-9

Basic information

• Product Name: Benzenepropanamide, N-(4-methylphenyl)-
• CAS NO: 71231-25-9
• Molecular Formula: C16H17NO
• Molecular Weight: 239.317
• Mol File: 71231-25-9.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Benzenepropanamide, N-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanamide, N-(4-methylphenyl)-(71231-25-9)
• EPA Substance Registry System: Benzenepropanamide, N-(4-methylphenyl)-(71231-25-9)

Safety Data

• Hazardous Substances Data: 71231-25-9(Hazardous Substances Data)

Upstream product

• 106-49-0 p-toluidine 
• 645-45-4 hydrocinnamic acid chloride 
• 100-42-5 styrene 
• 622-58-2 p-Tolylisocyanate 
• 179386-76-6 1-(1H-benzotriazol-1-yl)-3-phenylpropan-1-one 
• 501-52-0 3-Phenylpropionic acid 
• 151418-18-7 Aethoxykohlensaeure-dihydrozimtsaeure-anhydrid 
• 104-53-0 3-phenyl-propionaldehyde 
• 201230-82-2 carbon monoxide 
• 99-99-0 1-methyl-4-nitrobenzene 
• 6876-68-2 N-(4-methylphenyl)-3-phenyl-2-propenamide 
• 103-89-9 4-Methylacetanilide 
• 100-51-6 benzyl alcohol 
• 7625-64-1 p-tolyl-carbamic acid benzyl ester 

Downstream Products

• 792122-70-4 1-(p-tolyl)-3,4-dihydroquinolin-2(1H)-one 
• 122-97-4 3-Phenyl-1-propanol 
• 106-49-0 p-toluidine 
• 918518-70-4 C₁₇H₁₄ClN 
• 876893-56-0 N-[(1H-1,2,3-benzotriazol-1-yl)-3-phenylpropylidene]-N-(4-methylphenyl)amine 

Relevant articles and documents

Practical one-pot amidation of N -Alloc-, N -Boc-, and N -Cbz protected amines under mild conditions

A facile one-pot synthesis of amides from N-Alloc-, N-Boc-, and N-Cbz-protected amines has been described. The reactions involve the use of isocyanate intermediates, which are generated in situ in the presence of 2-chloropyridine and trifluoromethanesulfonyl anhydride, to react with Grignard reagents to produce the corresponding amides. Using this reaction protocol, a variety of N-Alloc-, N-Boc-, and N-Cbz-protected aliphatic amines and aryl amines were efficiently converted to amides with high yields. This method is highly effective for the synthesis of amides and offers a promising approach for facile amidation.

Method for selective reduction α, β - unsaturated carbonyl compound carbon-carbon double bond (by machine translation)

The invention discloses a method for selectively reducing carbon-carbon double bonds in α and β - unsaturated carbonyl compounds, which comprises the following steps of adding α, β - unsaturated carbonyl compounds shown in formula (I) in an electrolysis system and reducing α and β - unsaturated carbonyl compounds with carbonyl-conjugated carbon-carbon double bonds through an electrochemical cathodic reduction reaction. Compared with the reported method, the method disclosed by the invention does not use a metal catalyst and an external oxidant; and the reaction raw material and the electrolyte are low in price, nontoxic and tasteless, simple and convenient in post-treatment. (by machine translation)

Synthesis of Acetaminophen Analogues Containing α-Amino Acids and Fatty Acids for Inhibiting Hepatotoxicity

Acetaminophen is a popular antipyretic analgesic medicine that has weaker anti-inflammatory properties and lower incidence of side effects than nonsteroidal anti-inflammatory drugs (NSAIDs). However, acetaminophen causes hepatotoxicity due to the reactive metabolite N -acetyl- p -benzoquinone imine (NAPQI). We have obtained acetaminophen analogues in 57-99percent yields by using aniline derivatives with protected α-amino acids and fatty acids via the corresponding mixed carbonic carboxylic anhydrides in aqueous MeCN. We have also succeeded in synthesizing AM404 analogues in 76-97percent yields, which are expected to be promising candidates for reducing hepatotoxicity.