713-46-2Relevant articles and documents
Photophysical, photochemical and DNA binding studies of prepared phthalocyanines
Baran, Arif,?ol, Sumeyye,Karak?l??, Emel,?zen, Furkan
, (2020)
In this study, three phthalocyanine derivatives (M = Zn, Co, and metal-free) were synthesized using the corresponding ligand 4-(2-(4-(tert-butyl)phenoxy)ethoxy)phthalonitrile 2 in peripheral position, which was prepared from the reaction of 4-nitrophthalonitrile with 2-(4-(tert-butyl)phenoxy)ethan-1-ol 1. Metallophthalocyanine (MPc) and Metal-free phthalocyanine (H2Pc) derivatives, which have soluble groups in peripheral positions were synthesized. They are have high soluble in organic solvents depending on the appropriate position such as (tetrahydrofuran (THF), chloroform (CHCl3), methylene chloride (DCM), acetone (ACE), Dimethyl formamide (DMF), and dimethylsulphoxide (DMSO))….etc. The structures of Metallophthalocyanine (MPc) and Metal-free phthalocyanine (H2Pc) compounds 3a, 3b, and 3c were characterized using UV–vis spectroscopy, infrared (FT-IR) spectroscopy, and MALDI-TOF MS. Additionally, DNA binding, metal chelating effect assay, and DPPH [2,2-diphenyl-1-picrylhydrazyl hydrate] radical scavenging assay of MPcs H2Pc were investigated. In the interaction between Pc and CT-DNA the intrinsic binding constant (Kb) calculation was gave. Although the phthalocyanine compounds (3a, 3b and 3c) shoved low iron-containing iron chelating properties compared to EDTA, they can be said to have high metal chelating properties at the specified concentrations for this phthalocyanines. The DPPH radical scavenging activity of Pcs was elucidated according to the estimation of their in vitro antioxidant activities.
CARBOXYLIC ACIDS
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Page 17, (2010/02/05)
The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid compound represented by the formula (I), a salt thereof or a hydrate of them. In the formula, Ar represents a 6- to 14-membered aromatic ring group which may have at least one substituent; R1, R2, R3, R4, R5, R6, R7 and R8 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group; X represents an oxygen atom or a methylene group; Y represents a group represented by the formula (II) or (III): (wherein Z represents a group represented by the formula (IV): (wherein R9, R10, R11 and R12 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group)); m is 0 or 1; and n is 0 or 1.
T-Butyl-phenoxy-alkylene esters of benzoic and nicotinic acids, compositions containing same and their antihistaminic method of use
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, (2008/06/13)
p-Alkyl or cycloalkyl phenoxy alkanols and esters are provided having the structure: STR1 in which: R1 is an alkyl group having from one to six carbon atoms, preferably tertiary, and still more preferably tertiary-butyl; or a bivalent cycloalkylene group condensed with the phenyl group at adjacent ring carbons thereof, such as in indane; R2 is lower alkyl having from one to three carbon atoms or hydrogen; R3 is hydroxyl or an ester group selected from the group consisting of COOR4 and OOCR4 derived from unsubstituted and hydroxy-substituted monocarboxylic acids and COOR5 OOC and OOCR5 COO derived from unsubstituted and hydroxy-substituted dicarboxylic acids, the acids being selected from the group consisting of aliphatic acids, including carbamic acid, having from one to about twelve carbon atoms; cycloaliphatic acids having from three to about twelve carbon atoms; carbocyclic aromatic acids having from six to about twenty carbon atoms; and nitrogen heterocyclic aromatic acids having from five to about twelve carbon atoms, R4 being monovalent aliphatic, cycloaliphatic, aromatic, or nitrogen heterocyclic aromatic, and R5 being divalent aliphatic, cycloaliphatic, aromatic, or nitrogen heterocyclic aromatic, the acids being esterified with aliphatic alcohols having from one to six carbon atoms; and carbonic acid monoalkyl esters, the alkyl having from one to three carbon atoms; and n1, n2 and n3 represent the number of CH2, C(R2)2 and CH2 groups, respectively, and are numbers within the range from 0 to 10; and at least one of n1, n2 and n3 is other than zero. These compounds inhibit abnormal tissue reactivity due to specific allergic hypersensitivity or due to specific irritants by inhibiting the release of chemical mediators that are responsible for the symptoms of allergic diseases, including allergic rhinitis, asthma, hypersensitivity of the skin and of the gastrointestinal canal, and the many symptoms of irritation and inflammation produced by irritants and inflammation-causing substances.
