71319-21-6

Basic information

• Product Name: (4-methylphenyl)(3-nitrophenyl)methanone
• Synonyms: (3-Nitro-phenyl)-p-tolyl-methanone
• CAS NO: 71319-21-6
• Molecular Formula: C₁₄H₁₁NO₃
• Molecular Weight: 241.242
• Mol File: 71319-21-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 407.7°C at 760 mmHg
• Flash Point: 196.5°C
• Density: 1.232g/cm³
• Vapor Pressure: 7.39E-07mmHg at 25°C
• Refractive Index: 1.605
• CAS DataBase Reference: (4-methylphenyl)(3-nitrophenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-methylphenyl)(3-nitrophenyl)methanone(71319-21-6)
• EPA Substance Registry System: (4-methylphenyl)(3-nitrophenyl)methanone(71319-21-6)

Safety Data

• Hazardous Substances Data: 71319-21-6(Hazardous Substances Data)

Usage

Description

(4-methylphenyl)(3-nitrophenyl)methanone, also known as 3'-nitro-4'-methylbenzophenone, is an organic compound with the molecular formula C14H11NO3. It is a ketone derivative featuring a nitro group and a methyl group attached to phenyl rings, which contributes to its versatile applications in various industries.

Uses

Used in Organic Synthesis:
(4-methylphenyl)(3-nitrophenyl)methanone is used as an intermediate in the synthesis of various organic compounds due to its reactive functional groups, which can be further modified to produce a range of products.
Used in Pharmaceutical Production:
In the pharmaceutical industry, (4-methylphenyl)(3-nitrophenyl)methanone is used as a building block for the development of new drugs. Its unique structure allows it to be a key component in the creation of molecules with specific therapeutic properties.
Used in Agrochemicals:
(4-methylphenyl)(3-nitrophenyl)methanone also finds application in the agrochemical sector, where it serves as a starting material for the synthesis of various agrochemicals, such as pesticides and herbicides, that are essential for agricultural productivity.
It is important to handle (4-methylphenyl)(3-nitrophenyl)methanone with care, as it may pose potential hazards in a laboratory or industrial setting. Proper safety measures should be taken to minimize risks associated with its use.

Upstream product

• 108-88-3 toluene 
• 121-92-6 3-nitrobenzoic acid 
• 121-90-4 m-nitrobenzoic acid chloride 
• 3728-43-6 p-(trimethylsilyl)toluene 
• 15738-23-5 sodium tetrakis(4-tolyl)borate 
• 5720-05-8 4-methylphenylboronic acid 
• 99-61-6 3-nitro-benzaldehyde 
• 29559-27-1 1-methyl-4-(nitromethyl)benzene 
• 585-79-5 m-nitrobromobenzene 
• 106-38-7 para-bromotoluene 
• 34063-52-0 1-Nitro-3-nitromethyl-benzene 
• 3128-42-5 S-phenyl 4-methylbenzothioate 
• 13331-27-6 m-nitrobenzene boronic acid 
• 99-94-5 p-Toluic acid 

Downstream Products

• 62261-36-3 3-amino-4'-methyl-benzophenone 
• 100867-72-9 4'-methyl-3-nitro-benzophenone-hydrazone 
• 861075-01-6 3-bromo-4-methyl-3'-nitro-benzophenone 
• 433944-44-6 4-(3-nitrobenzoyl)benzoic acid 
• 873388-64-8 4-methyl-3,3'-dinitro-benzophenone 
• 861079-27-8 4-methyl-3,5,3'-trinitro-benzophenone 
• 34564-93-7 1-nitro-3-(1-p-tolylvinyl)benzene 
• 321879-67-8 4-benzoyl-2-bromotoluene 
• 860594-68-9 3'-amino-3-bromo-4-methyl-benzophenone 
• 58845-17-3 3,3'-diamino-4-methyl-benzophenone 
• 109044-72-6 diazo-(3-nitro-phenyl)-p-tolyl-methane 
• 1353654-34-8 1-(4-(3-nitrobenzoyl)benzoyl)-3-thiosemicarbazide 

Relevant articles and documents

Pd-NHC catalysed Carbonylative Suzuki coupling reaction and its application towards the synthesis of biologically active 3-aroylquinolin-4 (1H)-one and acridone scaffolds

We have unfolded a convenient and mild protocol for the synthesis of diaryl ketones via Pd- NHC catalysed carbonylative Suzuki coupling reaction. Notably, this method offers advantages like no use of toxic CO gas, shorter reaction time, high yield, and broad substrate scope. Several sensitive functional groups (like-COMe, -COOMe, -F, -Cl, -Br, -NH2, -CN) are well tolerated in this reaction. In addition, we have also demonstrated a new efficient route for the synthesis of biologically active and pharmaceutically important 2-substituted 3-Aroylquinolin-4(1H)-ones and acridone scaffolds.

Palladium-Catalyzed α-Arylation of Aryl Nitromethanes

Catalytic conditions for the α-arylation of aryl nitromethanes have been discovered using parallel microscale experimentation, despite two prior reports of the lack of reactivity of these aryl nitromethane precursors. The method efficiently provides a variety of substituted, isolable diaryl nitromethanes. In addition, it is possible to sequentially append two different aryl groups to nitromethane. Mild oxidation conditions were identified to afford the corresponding benzophenones via the Nef reaction, and reduction conditions were optimized to afford several diaryl methylamines.

Copper-catalyzed arylation of arylboronic acids with aldehydes

A novel copper-catalyzed arylation of arylboronic acids with aldehydes under oxygen atmosphere was achieved in the presence of Cu(OTf)2 and Xantphos, affording diaryl ketone derivatives in moderate to good yields. The efficiency of this reaction was demonstrated by the compatibility with fluoro, bromo, chloro, nitro, -methylsulfonyl, and trifluoromethyl groups. Georg Thieme Verlag Stuttgart ? New York.