7134-11-4

Basic information

• Product Name: POTASSIUM GUAIACOLSULFONATE
• Synonyms: GUAIACOLSULFONIC ACID POTASSIUM SALT HEMIHYDRATE;Guaiacolsulfonic Acid Potassium Salt 4-Hydroxy-3-methoxybenzenesulfonic Acid Potassium Salt Potassium 4-Hydroxy-3-methoxybenzenesulfonate;4-hydroxy-3-methoxybenzene-1-sulfonic acid
• CAS NO: 7134-11-4
• Molecular Formula: C₇H₈O₅S
• Molecular Weight: 204.2004
• EINECS: 230-434-8
• Product Categories: Classes of Metal Compounds;K (Potassium) Compounds (excluding simple potassium salts);Typical Metal Compounds
• Mol File: 7134-11-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.516 g/cm³
• CAS DataBase Reference: POTASSIUM GUAIACOLSULFONATE(CAS DataBase Reference)
• NIST Chemistry Reference: POTASSIUM GUAIACOLSULFONATE(7134-11-4)
• EPA Substance Registry System: POTASSIUM GUAIACOLSULFONATE(7134-11-4)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 7134-11-4(Hazardous Substances Data)

Usage

Uses

4-Hydroxy-3-methoxybenzenesulfonic Acid has been shown to have antitumor activity mice and rats inoculated with leukemia, adenocarcinoma, carcinosarcoma, and ovarian carcinoma cells.

Definition

ChEBI: An arenesulfonic acid that is guaiacol sulfated at position 4. Commonly used (in the form of its potassium salt) as an expectorant.

Upstream product

• 90-05-1 2-methoxy-phenol 

Downstream Products

• 7134-09-0 3,4-dihydroxybenzenesulfonic acid 
• 4097-63-6 2-methoxy-4,6-dinitrophenol 

Relevant articles and documents

Structure-reactivity correlations in the dissociative hydrolysis of 2′,4′-dinitrophenyl 4-hydroxy-X-benzenesulfonates

The hydrolysis reactions of several title esters in water at 60°C follow the rate law kobs = (ka + kb[OH-])/(1 + αH/Ka), where Ka is the ionization constant of the hydroxy group of the ester and kb is the second-order rate constant for the SN2(S) attack of hydroxide ion on the ionized ester. Hammett and Br?nsted correlations are consistent with a previous proposal that the mechanism related to ka is dissociative. An unusual relationship between ka values and redox equilibrium constants for substituted quinones is found to hold: this finding further supports the dissociative nature of the pathway related to ka.

Sulfonation and sulfation on reaction of 1,2-dihydroxybenzene and its methyl ethers in concentrated aqueous sulfuric acid

The homogeneous sulfonation of 1,2-dihydroxybenzene (1), its monomethyl (2) and dimethyl ether (3) in concentrated aqueous sulfuric acid at 25 deg C has been studied and isomer distributions, as well as rate coefficients for the sulfonation of 1-3 and their monosulfonic acids, have been determined.In 73.5-87.5percent H2SO4, 1 yields the 3- and 4-sulfonic acids in a ratio of 25:75, 2 yields the 4-, 5- and 6-sulfonic acids in a ratio of 46:36:18 in 73.5percent H2SO4 and 50:39:11 in 87.5percent H2SO4, whereas 3 yields only the 4-sulfonic acid.The remarkable absence of the 3-sulfonic acid (87.5percent H2SO4, the 4-sulfonic acid of 1 and the 5-sulfonic acid of 2 are present in part in the form of their hydrogen sulfate.In that acid region, the 3- and 4-sulfonic acids of 1 both yield the 3,5-disulfonic acid, the 4- and 6-sulfonic acids of 2 both yield the 4,6-disulfonic acid and the 4-sulfonic acid of 3 mainly yields the 4,6- together with some 4,5-disulfonic acid.