71370-05-3Relevant articles and documents
A Construction of α-Alkenyl Lactones via Reduction Radical Cascade Reaction of Allyl Alcohols and Acetylenic Acids
Zhang, Hua,Zhang, Guo-Min,He, Shuai,Shi, Zhi-Chuan,Zhang, Xiao-Mei,Wang, Ji-Yu
supporting information, p. 8337 - 8344 (2020/11/03)
An iron-catalyzed cascade reaction of radical reduction of allyl alcohols and acetylenic acids to construct polysubstituted α-alkenyl lactones has been developed. In this paper, various allyl alcohols can form allyl ester intermediates and are further transformed into alkyl radicals, which form products through intramolecular reflex-Michael addition. In addition, this method can be used to prepare spirocycloalkenyl lactones. Interestingly, this protocol can be used to synthesize the skeleton structure of natural products. Moreover, the product can be further transformed into a β-methylene tetrahydrofuran and tetrahydrofuran diene.
Reaction of Grignard reagents with carbonyl compounds under continuous flow conditions
Riva,Gagliardi,Martinelli,Passarella,Vigo,Rencurosi
experimental part, p. 3242 - 3247 (2010/05/19)
This contribution details how a continuous flow reactor was used to react carbonyl compounds with Grignard reagents at room temperature in an efficient and safe manner. Flow rate, residence time and temperature were optimized for the preparation of a small collection of secondary and tertiary alcohols. Excellent yields and general applicability were observed using the set-up protocol. The procedure was also applied for the preparation of Tramadol, an analgesic drug belonging to the opioid group. The developed conditions allowed the selective addition of Grignard reagents to aldehydes and ketones in the presence of a nitrile function.
Diene-ligated iridium complexes as catalysts for allylation and methallylation reactions of ketones
Barker, Timothy J.,Jarvo, Elizabeth R.
experimental part, p. 3259 - 3262 (2010/11/16)
An iridium-catalyzed allylation reactions of ketones using dienes as ligands has been developed. A variety of ketones underwent allylation and methallylation reactions at room temperature in good yields under these conditions. Competition experiments demonstrate that the reaction is selective for electron-deficient ketones. Georg Thieme Verlag Stuttgart New York.