71372-41-3

Basic information

• Product Name: 3-CHLORO-3'-METHYLBENZOPHENONE
• Synonyms: 3-CHLORO-3'-METHYLBENZOPHENONE
• CAS NO: 71372-41-3
• Molecular Formula: C₁₄H₁₁ClO
• Molecular Weight: 230.69
• Mol File: 71372-41-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 367.6°C at 760 mmHg
• Flash Point: 198.5°C
• Appearance: /
• Density: 1.178g/cm³
• Vapor Pressure: 1.35E-05mmHg at 25°C
• Refractive Index: 1.586
• CAS DataBase Reference: 3-CHLORO-3'-METHYLBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-3'-METHYLBENZOPHENONE(71372-41-3)
• EPA Substance Registry System: 3-CHLORO-3'-METHYLBENZOPHENONE(71372-41-3)

Safety Data

• Hazardous Substances Data: 71372-41-3(Hazardous Substances Data)

Usage

General Description

3-CHLORO-3'-METHYLBENZOPHENONE is a chemical compound with the molecular formula C14H11ClO. It is a benzophenone derivative with a chlorine atom attached to the third carbon atom and a methyl group attached to the third carbon of one of the phenyl rings. 3-CHLORO-3'-METHYLBENZOPHENONE is commonly used as a photoinitiator in the production of polymers and coatings, as well as a component in UV-curable inks and adhesives. It is also used in the manufacturing of plastics, dyes, and pharmaceuticals. 3-CHLORO-3'-METHYLBENZOPHENONE is known for its ability to absorb UV radiation and initiate polymerization reactions, making it a valuable component in various industrial applications.

InChI:InChI=1/C14H11ClO/c1-10-4-2-5-11(8-10)14(16)12-6-3-7-13(15)9-12/h2-9H,1H3

Upstream product

• 201230-82-2 carbon monoxide 
• 456-39-3 3-chlorobenzenediazonium tetrafluoroborate 
• 937-01-9 trimethyl(3-methylphenyl)stannane 
• 21436-44-2 3-methylbenzoic acid anhydride 
• 7519-92-8 tris(3-chlorophenyl)boroxine 
• 134-62-3 N,N-Diethyl-3-methylbenzamide 
• 30070-63-4 meta-chlorobenzoic anhydride 
• 7294-50-0 tri-o-tolylboroxine 

Downstream Products

• 1267636-78-1 3-(3-chlorobenzoyl)benzaldehyde 

Relevant articles and documents

Redox-Neutral ortho Functionalization of Aryl Boroxines via Palladium/Norbornene Cooperative Catalysis

Palladium/norbornene (Pd/NBE) cooperative catalysis, also known as the Catellani reaction, has become an increasingly useful method for site-selective arene functionalization; however, certain constraints still exist because of its intrinsic mechanistic pathway. Herein, we report a redox-neutral ortho functionalization of aryl boroxines via Pd/NBE catalysis. An electrophile, such as carboxylic acid anhydrides or O-benzoyl hydroxylamines, is coupled at the boroxine ortho position, and a proton as the second electrophile is introduced at the ipso position. This reaction does not require extra oxidants or reductants and avoids stoichiometric bases or acids, thereby tolerating a wide range of functional groups. In particular, orthogonal chemoselectivity between aryl iodide and boroxine moieties is demonstrated, which could be used to control reaction sequences. Finally, a deuterium-labeling study supports the ipso protonation pathway. This unique mechanistic feature could inspire the development of a new class of Pd/NBE-catalyzed transformations.Poly-substituted aromatics are ubiquitously found in drugs and agrochemicals. To realize streamlined synthesis, it is highly attractive if functional groups can be site-selectively introduced at unactivated positions with common arene starting materials. Here, a method is developed to directly introduce acyl and amino groups at unactivated ortho positions of readily available aryl boron compounds. Compared with the known ortho functionalization approaches, this method does not require stoichiometric bases, external oxidants, or reductants. Consequently, the reaction is chemoselective: a wide range of functional groups, including highly reactive aryl iodides, can be tolerated. The primary innovation lies in the use of a proton to terminate the ipso aryl intermediate and regenerate the active palladium catalyst. This unique mode of reactivity in the palladium/norbornene catalysis should open the door for developing new redox-neutral methods for site-selective arene functionalization.A redox-neutral ortho functionalization of aryl boroxines via palladium/norbornene cooperative catalysis is developed. The ortho amination and acylation are achieved with carboxylic acid anhydrides and O-benzoyl hydroxylamines as an electrophile, respectively, whereas protonation occurs at the ipso position. This transformation avoids using either extra oxidants and reductants or stoichiometric bases and acids. In addition, orthogonal chemoselectivity between aryl iodide and boroxine moieties is demonstrated for pathway divergence.

New synthesis of biaryls via Rh-catalyzed decarbonylative Suzuki-coupling of carboxylic anhydrides with arylboroxines

The catalytic cross-coupling of aromatic carboxylic anhydrides or acid chlorides with triarylboroxines has been achieved for the first time under decarbonylation, giving rise to the unsymmetrical biaryls rather than the expected diaryl ketones. This new decarbonylative Suzuki coupling, catalyzed by a [Rh(ethylene)2Cl]2/KF system, can be applied to aromatic, heteroaromatic and vinylic carboxylic anhydrides, potentially opening up new perspectives for the use of carboxylic acid derivatives as substrates in biaryl syntheses.

Benzophenones and benzhydrols

Compounds having the formula STR1 WHERE X is --CO-- or --CHOH--, Y and Z are halogen, alkyl, trifluoromethyl, alkoxy, hydroxy, nitro, cyano, carboxy, carbalkoxy, carbamoyl, or alkylthio, and m and n are 0, 1, or 2 Are useful in controlling undesirable secondary growth in plants, particularly sucker growth in tobacco.