71376-57-3

Basic information

• Product Name: p-tolyl 2-phenyl-2-propyl sulfone
• CAS NO: 71376-57-3
• Molecular Weight: 274.384
• Mol File: 71376-57-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: p-tolyl 2-phenyl-2-propyl sulfone(CAS DataBase Reference)
• NIST Chemistry Reference: p-tolyl 2-phenyl-2-propyl sulfone(71376-57-3)
• EPA Substance Registry System: p-tolyl 2-phenyl-2-propyl sulfone(71376-57-3)

Safety Data

• Hazardous Substances Data: 71376-57-3(Hazardous Substances Data)

Upstream product

• 74-83-9 methyl bromide 
• 24422-77-3 1-methyl-4-[(1-phenylethyl)sulfonyl]benzene 
• 98821-09-1 toluene-4-sulfinic acid-(1-methyl-1-phenyl-ethyl ester) 
• 98-59-9 p-toluenesulfonyl chloride 
• 536-57-2 p-toluene sulfinic acid 
• 617-94-7 1-methyl-1-phenylethyl alcohol 

Relevant articles and documents

Silver-Catalyzed C(sp3)-H Sulfonylation for the Synthesis of Benzyl Sulfones Using Toluene Derivatives and α-Amino Acid Sulfonamides

We describe a simple and practical protocol for the synthesis of benzyl sulfones using readily available toluene derivatives and α-amino acid sulfonamides. The reaction proceeds to afford a broad range of benzyl sulfones in moderate to high yields under silver catalysis. The mechanism possibly involves a Minisci-type formation of α-aminoalkyl radical, homolytic cleavage of a N-S bond to generate a sulfonyl radical, and coupling of sulfonyl radical with a benzyl radical formed via hydrogen abstraction by sulfate anion radical. The practicality of the present reaction is demonstrated by a gram-scale synthesis and one-step synthesis of anticancer-active compound. The mechanism studies are conducted using radical scavengers and deuterated toluene.