714-72-7 Usage
General Description
"(2,4-Dioxo-1,3-diazaspiro[4.4]non-3-yl) acetic acid" is a complex organic compound that is characterized by its unique spirocyclic structure. The term ‘spiro’ indicates that the compound is made up of two or more rings that share a common atom, which in this case is a nitrogen atom. The ‘dioxo’ notation signifies that the compound possesses two carbonyl groups (C=O), and the ‘1,3-diazaspiro’ part indicates that there are two nitrogen (N) atoms in the first and third positions of the ring structure. Finally, the ‘acetic acid’ part denotes the presence of a carboxylic acid functional group (COOH). (2,4-Dioxo-1,3-diazaspiro[4.4]non-3-yl)acetic acid is categorized under heterocyclic compounds, meaning it consists of rings that contain at least one atom that is not carbon. Its specific properties, such as reactivity or uses, are not universally recognized.
Check Digit Verification of cas no
The CAS Registry Mumber 714-72-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,1 and 4 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 714-72:
(5*7)+(4*1)+(3*4)+(2*7)+(1*2)=67
67 % 10 = 7
So 714-72-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H12N2O4/c12-6(13)5-11-7(14)9(10-8(11)15)3-1-2-4-9/h1-5H2,(H,10,15)(H,12,13)
714-72-7Relevant articles and documents
An Old Story in the Parallel Synthesis World: An Approach to Hydantoin Libraries
Bogolubsky, Andrey V.,Moroz, Yurii S.,Savych, Olena,Pipko, Sergey,Konovets, Angelika,Platonov, Maxim O.,Vasylchenko, Oleksandr V.,Hurmach, Vasyl V.,Grygorenko, Oleksandr O.
, p. 35 - 43 (2018/01/17)
An approach to the parallel synthesis of hydantoin libraries by reaction of in situ generated 2,2,2-trifluoroethylcarbamates and α-amino esters was developed. To demonstrate utility of the method, a library of 1158 hydantoins designed according to the lead-likeness criteria (MW 200-350, cLogP 1-3) was prepared. The success rate of the method was analyzed as a function of physicochemical parameters of the products, and it was found that the method can be considered as a tool for lead-oriented synthesis. A hydantoin-bearing submicromolar primary hit acting as an Aurora kinase A inhibitor was discovered with a combination of rational design, parallel synthesis using the procedures developed, in silico and in vitro screenings.
