714-88-5

Basic information

• Product Name: 1,5-dioxaspiro[5.5]undecane-3,3-diyldimethanol
• CAS NO: 714-88-5
• Molecular Formula: C₁₁H₂₀O₄
• Molecular Weight: 216.2741
• Mol File: 714-88-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 365.6°C at 760 mmHg
• Flash Point: 174.9°C
• Density: 1.19g/cm³
• Vapor Pressure: 7.93E-07mmHg at 25°C
• Refractive Index: 1.523
• CAS DataBase Reference: 1,5-dioxaspiro[5.5]undecane-3,3-diyldimethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-dioxaspiro[5.5]undecane-3,3-diyldimethanol(714-88-5)
• EPA Substance Registry System: 1,5-dioxaspiro[5.5]undecane-3,3-diyldimethanol(714-88-5)

Safety Data

• Hazardous Substances Data: 714-88-5(Hazardous Substances Data)

Usage

Structure

Dioxaspiro ring with two hydroxyl functional groups

Functional groups

Hydroxyl (-OH)

Applications

a. Building block or intermediate in organic synthesis
b. Production of polymers and pharmaceuticals
c. Manufacture of surfactants, lubricants, and specialty chemicals

Industries

Chemical, pharmaceutical, polymer, and specialty chemical industries

Interest

Researchers and manufacturers due to its structural and functional properties

Upstream product

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Downstream Products

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Relevant articles and documents

Synthesis, surface-active properties, and anthelmintic activities of new cationic gemini surfactants against the gastrointestinal nematode, heligmosomoides polygyrus bakeri, in vitro

A novel series of cationic dimeric surfactants was prepared involving the ketalization reaction, Williamson etherification, and regioselective oxirane ring opening with tertiary alkyl amines. The synthesized compounds were obtained in high purity by a simple purification procedure using column chromatography. The critical micelle concentration (CMC), effectiveness of surface tension reduction (γCMC), surface excess concentration (λ), and area per molecule at the interface (A) were determined and values indicate that the cationic series is characterized by good surface-active and self-aggregation properties. For the first time, we reported the anthelmintic activities against the rodent gastrointestinal nematode Heligmosomoides polygyrus bakeri, in vitro for cationic gemini compounds. In the series of five tested cationic compounds (4a-e), three of them (4a, 4b and 4d) were shown to have an excellent anthelmintic activity in vitro at different concentrations. The anthelmintic activity was found to be dependent on the type of cationic compound, concentration and incubation time. The cationic di-C12 (4a) derivate of the series was the best anthelmintic agent, its use was optimal at a minimum concentration of 50 ppm and with 60 min of incubation. AOCS 2012.

METHOD FOR MANUFACTURING (METH)ACRYLOYL GROUP-CONTAINING POLYOL COMPOUND, (METH)ACRYLOYL GROUP-CONTAINING POLYOL COMPOUND, AND URETHANE (METH)ACRYLATE

To provide a simple, efficient method for manufacturing a (meth)acryloyl group-containing polyol compound, a (meth)acryloyl group-containing polyol compound produced by the manufacturing method, and an urethane (meth)acrylate produced by using the compound.A method for manufacturing a (meth)acryloyl group-containing polyol compound (x3) includes the steps of producing a hydroxyl group-containing ketal compound (x1) by reacting a polyol compound (A) having at least three hydroxyl groups in the molecular structure with a cyclic ketone compound (B) at the proportion in which the ratio [(OH)/(CO)] of the number of moles of hydroxyl groups (OH) included in the polyol compound (A) to the number of moles of carbonyl groups (CO) included in the cyclic ketone compound (B) falls within the range of 3 to 12 in an organic solvent (S) in the presence of an acid catalyst, producing a (meth)acrylate compound (x2) by (meth)acrylating hydroxyl groups included in the resulting hydroxyl group-containing ketal compound (x1), and hydrolyzing the resulting (meth)acrylate compound (x2).

Synthesis of two new enrichable and MS-cleavable cross-linkers to define protein-protein interactions by mass spectrometry

The cross-linking Mass Spectrometry (XL-MS) technique extracts structural information from protein complexes without requiring highly purified samples, crystallinity, or large amounts of material. However, there are challenges to applying the technique to protein complexes in vitro, and those challenges become more daunting with in vivo experiments. Issues include effective detection and identification of cross-linked peptides from complex mixtures. While MS-cleavable cross-linkers facilitate the sequencing and identification of cross-linked peptides, enrichable cross-linkers increase their detectability by allowing their separation from non-cross-linked peptides prior to MS analysis. Although a number of cross-linkers with single functionality have been developed in recent years, an ideal reagent would incorporate both capabilities for XL-MS studies. Therefore, two new cross-linkers have been designed and prepared that incorporate an azide (azide-A-DSBSO) or alkyne (alkyne-A-DSBSO) to enable affinity purification strategies based on click chemistry. The integration of an acid cleavage site next to the enrichment handle allows easy recovery of cross-linked products during affinity purification. In addition, these sulfoxide containing cross-linking reagents possess robust MS-cleavable bonds to facilitate fast and easy identification of cross-linked peptides using MS analysis. Optimized, gram-scale syntheses of these cross-linkers have been developed and the azide-A-DSBSO cross-linker has been evaluated with peptides and proteins to demonstrate its utility in XL-MS analysis.