7146-26-1

Basic information

• Product Name: 2-AMinothiazol-4-ol
• Synonyms: 2-Amino-4-hydroxythiazole;NSC 23261
• CAS NO: 7146-26-1
• Molecular Formula: C₃H₄N₂OS
• Molecular Weight: 116.14166
• Mol File: 7146-26-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 329.7°C at 760 mmHg
• Flash Point: 153.2°C
• Appearance: /
• Density: 1.594g/cm³
• Vapor Pressure: 9.08E-05mmHg at 25°C
• Refractive Index: 1.722
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-AMinothiazol-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMinothiazol-4-ol(7146-26-1)
• EPA Substance Registry System: 2-AMinothiazol-4-ol(7146-26-1)

Safety Data

• Hazardous Substances Data: 7146-26-1(Hazardous Substances Data)

Usage

General Description

2-Aminothiazol-4-ol is a chemical compound with the molecular formula C3H4N2OS. It is a heterocyclic compound containing both nitrogen and sulfur atoms. 2-AMinothiazol-4-ol has been used in pharmaceutical research and drug development due to its potential biological activities, such as anticonvulsant and anti-inflammatory properties. It has also been studied for its potential use as a building block in the synthesis of other organic compounds. Additionally, 2-Aminothiazol-4-ol has been investigated for its potential role as a corrosion inhibitor in metal protection. Overall, this compound has shown promise in various areas of research and has potential applications in pharmaceuticals, organic synthesis, and materials science.

InChI:InChI=1/C3H4N2OS/c4-3-5-2(6)1-7-3/h1,6H,(H2,4,5)

Upstream product

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• 105-39-5 chloroacetic acid ethyl ester 

Relevant articles and documents

Synthesis and characterization of new azo dyes based on thiazole and assess the biological and laser efficacy for them and study their dyeing application

The aim of this work describes the synthesis of disperse dyes in the derivative of 2-amino -4-hydroxy thiazole, which can be used as dyes for polyester fabrics with orange and red color They were obtained by preparing, (2-amino-4- hydroxy- thiazole), then the latter compound was diazotization and couplings to produced (compound III and IV), Which were introduced by another coupling with diazonium salt of compound I diazotization to synthesize disperse (VII,VIII). The synthesized heterocyclic and synthesized dyes were studied by UV Spectroscopy, FT-IR, 1H-NMR and 13C-NMR. The substituted dyes Penetrate with good depth on polyester fabrics with a shade of orange and red colors, respectively. That increase heteroatoms and the conjugation in the dyes structure lead to high redshifts and the brightness of shades, color stability is high and fastness properties. The antibacterial activities were studied against different kinds of bacteria, namely Eschershia coli and Klebsiella Pneumonia Gram (-) ve, Staphylococcus aureus and Staphylococcus epidermidis Gram (+) ve. In addition, evaluation of laser efficacy was showed for the compounds (I,III,IV,VII,VIII) were radiated by laser for (10, 20, 30) seconds, It was observed that the prepared compounds were not affected and did not polymerize or degradation when measuring melting point and color.

The synthesis of two potent β-3 adrenergic receptor agonists

This contribution describes the initial preparation of two potent β-3 receptor agonists 1 and 2. Subsequent scale up of these two compounds was required for further evaluation and proceeded via a common key amine intermediate 24. Synthesis of this key intermediate by way of a Ritter reaction was a vital step in the sequence. Enantioselective Noyori hydrogenation reactions gave access to the chiral epoxides necessary to make the target compounds. Chemistry was developed for the selective dehalogenation of the 2-chloropyridyl group in the presence of a sensitive isoxazole unit to provide access to 1.