7146-63-6 Usage
Description
Methyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoate, also known as IMDPH, is a chemical compound with a molecular formula C19H15NO4. It is a derivative of isoindolinone, which is commonly used in the synthesis of pharmaceuticals and agrochemicals. IMDPH has potential biological activity, particularly as a dipeptidyl peptidase IV (DPP-4) inhibitor, making it an interesting candidate for the treatment of type 2 diabetes. Its chemical structure and properties make it an important molecule for medicinal chemistry research and drug development.
Uses
Used in Pharmaceutical Industry:
IMDPH is used as a DPP-4 inhibitor for the treatment of type 2 diabetes. As a DPP-4 inhibitor, it helps to increase the levels of incretin hormones, which in turn stimulates insulin secretion and lowers blood glucose levels. This makes it a potential therapeutic agent for managing diabetes and improving glycemic control.
Used in Medicinal Chemistry Research:
IMDPH is used as a key molecule in medicinal chemistry research for the development of new drugs and therapeutic agents. Its unique chemical structure and properties make it a valuable compound for exploring novel drug targets and designing innovative pharmaceuticals.
Used in Agrochemical Industry:
Although not explicitly mentioned in the provided materials, given its use in the synthesis of agrochemicals, IMDPH could potentially be used as an intermediate or active ingredient in the development of agrochemicals for pest control, crop protection, or other agricultural applications. Its specific use in this industry would depend on further research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 7146-63-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,1,4 and 6 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 7146-63:
(6*7)+(5*1)+(4*4)+(3*6)+(2*6)+(1*3)=96
96 % 10 = 6
So 7146-63-6 is a valid CAS Registry Number.
7146-63-6Relevant articles and documents
Anchimetric Assistance in Hydrogen Atom Transfer Reactions on the Side Chains of Amino Acid Derivatives
Easton, Christopher J.,Merrett, Martin C.
, p. 3035 - 3036 (1996)
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Stereoselective synthesis of chiral α-amino-β-lactams through palladium(II)-catalyzed sequential monoarylation/amidation of C(sp 3)-H Bonds
Zhang, Qi,Chen, Kai,Rao, Weihao,Zhang, Yuejun,Chen, Fa-Jie,Shi, Bing-Feng
, p. 13588 - 13592 (2014/01/06)
Give Me an Ar, give Me an N! Arylation of the methyl group in a simple derivative of readily available alanine under palladium catalysis was followed by intramolecular amidation at the same position to give chiral α-amino-β-lactams with a wide range of aryl substituents (see scheme; Phth=phthaloyl). The α-amino-β-lactams were obtained in moderate to high yields with good functional-group tolerance and high diastereoselectivity. Copyright
A mild, selective, PyBOP mediated procedure for the conversion of primary Amines into phthalimides
Aguilar, Núria,Moyano, Albert,Pericàs, Miquel A.,Riera, Antoni
, p. 313 - 316 (2007/10/03)
A new method for the protection of primary amines or amino alcohols as phthalimides is described. The phthaloyl group is selectively introduced under mild, anhydrous conditions by reacting the amine with 2- (ethoxycarbonyl)benzoic acid activated by PyBOP, followed by the thermally induced cyclization of the resulting phthalamic ester. These reaction conditions are applicable to a variety of primary amines and good yields are obtained in all cases.
