7147-89-9

Basic information

• Product Name: 4-CHLORO-6-NITRO-M-CRESOL
• Synonyms: 4-CHLORO-6-NITRO-M-CRESOL;4-CHLORO-5-METHYL-2-NITROPHENOL;4-CHLORO-3-METHYL-6-NITROPHENOL;4-chloro-5-methyl-2-nitro-pheno;4-CHLORO-6-NITRO-META-CRESOL, 99%;4-CHLORO-6-NITRO-M-CRESOL,99%;4-CHLORO-6-NITRO-METALPHA-CRESOL 99%;4-Chloro-3-methyl-6-nitrophenol,4-Chloro-6-nitro-m-cresol
• CAS NO: 7147-89-9
• Molecular Formula: C₇H₆ClNO₃
• Molecular Weight: 187.58
• EINECS: 230-461-5
• Mol File: 7147-89-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 132-134 °C(lit.)
• Boiling Point: 276.7 °C at 760 mmHg
• Flash Point: 121.1 °C
• Appearance: /
• Density: 1.4219 (rough estimate)
• Vapor Pressure: 0.00281mmHg at 25°C
• Refractive Index: 1.6000 (estimate)
• PKA: 6.51±0.27(Predicted)
• CAS DataBase Reference: 4-CHLORO-6-NITRO-M-CRESOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-6-NITRO-M-CRESOL(7147-89-9)
• EPA Substance Registry System: 4-CHLORO-6-NITRO-M-CRESOL(7147-89-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 7147-89-9(Hazardous Substances Data)

Usage

Uses

4-Chloro-3-methyl-6-nitrophenol was used to evaluate toxicity in Tetrahymena pyriformis by quantitative structure-toxicity relationships-topological substructural molecular design method.

InChI:InChI=1/C7H6ClNO3/c1-4-2-7(10)6(9(11)12)3-5(4)8/h2-3,10H,1H3/p-1

Upstream product

• 59-50-7 4-Chloro-3-methylphenol 
• 700-38-9 2-nitro-5-methylphenol 
• 35458-35-6 5-chloro-2-hydroxy-4-methyl-benzoic acid 
• 112135-31-6 2-bromo-4-chloro-5-methylphenol 
• 64-19-7 acetic acid 
• 54963-43-8 4-chloro-3-methylphenyl acetate 
• 182913-38-8 5-methyl-2-nitrophenyl acetate 
• 7782-50-5 chlorine 
• 7697-37-2 nitric acid 

Downstream Products

• 101080-03-9 1-chloro-4-methoxy-2-methyl-5-nitro-benzene 
• 55229-54-4 2-bromo-4-chloro-3-methyl-6-nitro-phenol 
• 53524-27-9 2-amino-4-chloro-5-methylphenol 
• 108401-62-3 2-(4-cloro-5-metil-2-nitrofenossi)-N,N,N',N'-tetraetilmalonammide 
• 27997-60-0 4-chloro-5-methyl-2-nitrophenyl acetate 
• 3938-12-3 5-chloro-1,2-dihydroxy-4-methylbenzene 
• 851190-66-4 2-methyl-2-(4-chloro-5-methyl-2-nitrophenoxy)propionic acid ethyl ester 
• 569688-67-1 5-chloro-2-methoxy-4-methylphenylamine 
• 886981-68-6 4-amino-2-chloro-5-methoxy-benzaldehyde 
• 886981-67-5 N-(5-chloro-4-formyl-2-methoxy-phenyl)-2,2,2-trifluoro-acetamide 
• 886981-66-4 N-(4-bromomethyl-5-chloro-2-methoxy-phenyl)-2,2,2-trifluoro-acetamide 
• 886981-69-7 1-(5-chloro-4-formyl-2-methoxy-phenyl)-3-(5-cyano-pyrazin-2-yl)-urea 
• 851190-75-5 2-methyl-2-(4-chloro-5-methyl-2-nitrophenoxy)propionamide 
• 851190-70-0 2-methyl-2-(4-chloro-5-methyl-2-nitrophenoxy)propionic acid 

Relevant articles and documents

ANTIBIOTIC COMPOUNDS

The present invention relates to antibiotic compounds of formula (I), to compositions containing these compounds and to methods of treating bacterial diseases and infections using the compounds. The compounds find application in the treatment of infection with, and diseases caused by, Gram-positive and/or Gram-negative bacteria, and in particular in the treatment of infection with, and diseases caused by, Neisseria gonorrhoeae.

Improved Protocol for Mononitration of Phenols with Bismuth(III) and Iron(III) Nitrates

A simple and efficient multigram procedure was developed for the selective mononitration of various activated phenols. The reaction proceeded smoothly with 0.5 equivalents of Bi(NO3)3 · 5H2O or Fe(NO3)3 · 9H2O in acetone at ambient temperature or at reflux. The desired products were isolated in 62-93% total yield and essentially no overnitrated compounds were detected.

Ethylammonium nitrate (EAN)/Tf2O and EAN/TFAA: Ionic liquid based systems for aromatic nitration

Acting as in situ sources of triflyl nitrate (TfONO2) and trifluoroacetyl nitrate (CF3COONO2), the EAN/Tf 2O and EAN/TFAA systems, generated via metathesis in the readily available ethylammonium nitrate (EAN) ionic liquid as solvent, are powerful electrophilic nitrating reagents for a wide variety of aromatic and heteroaromatic compounds. Comparative nitration experiments indicate that EAN/Tf2O is superior to EAN/TFAA for nitration of strongly deactivated systems. Both systems exhibit low substrate selectivity (K T/KB = 5-10) in (Figure presented) between values reported for covalent nitrates and preformed nitronium salts.