71486-42-5

Basic information

• Product Name: alpha-[2-(dimethylamino)ethyl]-alpha-phenylpyridine-2-acetonitrile
• Synonyms: alpha-[2-(dimethylamino)ethyl]-alpha-phenylpyridine-2-acetonitrile;4-Dimethylamino-2-phenyl-2-(2-pyridyl)butanenitrile
• CAS NO: 71486-42-5
• Molecular Formula: C₁₇H₁₉N₃
• Molecular Weight: 265.35286
• EINECS: 275-514-3
• Mol File: 71486-42-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: alpha-[2-(dimethylamino)ethyl]-alpha-phenylpyridine-2-acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: alpha-[2-(dimethylamino)ethyl]-alpha-phenylpyridine-2-acetonitrile(71486-42-5)
• EPA Substance Registry System: alpha-[2-(dimethylamino)ethyl]-alpha-phenylpyridine-2-acetonitrile(71486-42-5)

Safety Data

• Hazardous Substances Data: 71486-42-5(Hazardous Substances Data)

Upstream product

• 109-09-1 2-chloropyridine 
• 50599-78-5 4-dimethylamino-2-phenyl-butyronitrile 
• 109-04-6 2-bromo-pyridine 
• 5005-36-7 phenyl-pyridin-2-yl-acetonitrile 
• 107-99-3 2-(dimethylamino)ethyl chloride 

Relevant articles and documents

Reaction of 4-(N,N-dimethylamino)-2-phenyl-2-(2-pyridyl)butanenitrile and related compounds with ethyl chloroformate; formation of indolizinium and quinolizinium chlorides

4-(N,N-Dialkylamino)-2-phenyl-2-(2-pyridyl)butanenitriles (10, 11 and 12) and 5-(N,N-dimethylamino)-2-phenyl-2-(2-pyridyl)pentanenitrile (13) react with ethyl chloroformate, via a cyclization-N-dealkylation process, to give indolizinium and quinolizinium salts (1 and 2). Compounds 1 and 2 are also obtained by reaction of the alcohol derivatives 14 and 15 with thionyl chloride. Reaction of 2-phenyl-2-(2-pyridyl)ethanenitrile (9) in the presence of potassium hydroxide in dimethyl sulfoxide, leading to [2-hydroxy-2-phenyl-2-(2-pyridyl)ethyl]methylsulfoxide (21), is also described.