7149-44-2Relevant articles and documents
Fluorescent probe for tumor diagnosis and treatment as well as preparation method and application of fluorescent probe
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Paragraph 0112-0118, (2019/03/24)
The invention provides a fluorescent probe for tumor diagnosis and treatment as well as a preparation method and an application of the fluorescent probe. In the fluorescent probe, an azacyclo structure base is taken as an H receptor, a near infrared fluorescent dye with high extinction coefficient and tumor targeting effect is taken as a fluorophore, then the OFF-ON type probe capable of regulating fluorescence intensity by rapid PET (photoinduced electron transfer) process is formed, fluorescence of the probe is strengthened in a slightly acidic environment of tumor, tumor detection is realized, the probe has strong PA (photoacoustic) signals at the tumor while fluorescence imaging is performed, and tumor boundary can be determined accurately by NIRF/PA bimodal imaging. The fluorescentprobe also has good photo-thermal treatment effect on the tumor and can be used for preparing corresponding tumor treatment drugs.
Design, synthesis, and evaluation of unsymmetrical difluoro-boron complexes with imidazoline as potential fungicides
Wang, Kewei,Cui, Jingnan,Xie, Lijuan,Qian, Xuhong
experimental part, p. 418 - 424 (2010/08/05)
A series of unsymmetrical difluoroboron (BF2) complexes with pyridine and imidazoline were synthesized by reaction of new chelating ligands (arylmethyl-imidazolidinylidene)-pyridin-2-yl-amine with boron trifluoride diethyl etherate. All the ligands and BF2 complexes were structurally characterized by IR, HRMS, 1H, 13C, 11B, and 19F NMR,indicating the bidentate complexation of imidazoline nitrogen and the pyridine nitrogen to the boron center. Evaluation of agricultural bioactivities showed that some of the BF2 complexes exhibited moderate fungicidal activities, and most of the BF2 complexes exhibited higher activities than the none-BF2 complexed substrates.
Imidazolidinones as brain activators
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, (2008/06/13)
This invention relates to imidazolidinone compounds of the formula STR1 wherein Q is methylene group or a single bond: R is a heterocyclic group selected from the group consisting of pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl and 1,3-thiazolyl which may be unsubstituted or with a substituent selected from the group consisting of lower alkyl, lower alkoxy and halogen atom, wherein R is bonded to Q or, when Q is a single bond, to the imidazolidinone ring, through the carbon atom of R; the ring A is an unsubstituted phenyl or a substituted phenyl having 1 or 2 substituent(s) selected from the group consisting of lower alkyl, lower alkoxy, halogen, lower alkylthio, trihalogeno-lower alkyl and nitro; Y is vinylene group or ethynylene; m is a integer from 1 to 6 and n is 0, 1 or 2, or a pharmacetically acceptable salt thereof. These compounds aer useful as cerebral activators, anti-depressants and nootropic drugs.