714963-89-0

Basic information

• Product Name: {3-[((2R,3S,4S,5R,6R)-6-{(2R,3R,4S,5S,6R)-6-[(4-Benzyloxycarbonylamino-butyrylamino)-methyl]-3,4,5-trihydroxy-tetrahydro-pyran-2-yloxy}-3,4,5-trihydroxy-tetrahydro-pyran-2-ylmethyl)-carbamoyl]-propyl}-carbamic acid benzyl ester
• Synonyms: {3-[((2R,3S,4S,5R,6R)-6-{(2R,3R,4S,5S,6R)-6-[(4-Benzyloxycarbonylamino-butyrylamino)-methyl]-3,4,5-trihydroxy-tetrahydro-pyran-2-yloxy}-3,4,5-trihydroxy-tetrahydro-pyran-2-ylmethyl)-carbamoyl]-propyl}-carbamic acid benzyl ester
• CAS NO: 714963-89-0
• Molecular Weight: 778.811
• Mol File: 714963-89-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {3-[((2R,3S,4S,5R,6R)-6-{(2R,3R,4S,5S,6R)-6-[(4-Benzyloxycarbonylamino-butyrylamino)-methyl]-3,4,5-trihydroxy-tetrahydro-pyran-2-yloxy}-3,4,5-trihydroxy-tetrahydro-pyran-2-ylmethyl)-carbamoyl]-propyl}-carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {3-[((2R,3S,4S,5R,6R)-6-{(2R,3R,4S,5S,6R)-6-[(4-Benzyloxycarbonylamino-butyrylamino)-methyl]-3,4,5-trihydroxy-tetrahydro-pyran-2-yloxy}-3,4,5-trihydroxy-tetrahydro-pyran-2-ylmethyl)-carbamoyl]-propyl}-carbamic acid benzyl ester(714963-89-0)
• EPA Substance Registry System: {3-[((2R,3S,4S,5R,6R)-6-{(2R,3R,4S,5S,6R)-6-[(4-Benzyloxycarbonylamino-butyrylamino)-methyl]-3,4,5-trihydroxy-tetrahydro-pyran-2-yloxy}-3,4,5-trihydroxy-tetrahydro-pyran-2-ylmethyl)-carbamoyl]-propyl}-carbamic acid benzyl ester(714963-89-0)

Safety Data

• Hazardous Substances Data: 714963-89-0(Hazardous Substances Data)

Upstream product

• 42891-34-9 2,2',3,3',4,4'-hex-O-acetyl-6,6'-dideoxy-6,6'-dibromo-α,α-D-trehalose 
• 23103-34-6 2,3,4-tri-O-acetyl-6-azido-6-deoxy-α-D-glucopyranosyl-(1→1)-2,3,4-tri-O-acetyl-6-azido-6-deoxy-α-D-glucopyranoside 
• 5105-78-2 4-(benzyloxycarbonylamino)butyric acid 
• 30923-00-3 6,6'-diamino-6,6'-dideoxy-α,α-D-trehalose 

Relevant articles and documents

α,α-Trehalose derivatives bearing guanidino groups as inhibitors to HIV-1 Tat-TAR RNA interaction in human cells

Replication of HIV-1 requires specific interactions of Tat protein with TAR RNA. Disruption of Tat-TAR RNA interaction could inhibit HIV-1 replication. Here four target compounds were designed and synthesized to bind to TAR RNA for blocking the interaction of Tat-TAR RNA. The core molecule 6,6 ′-diamino-6,6′-dideoxy-α,α- trehalose was obtained from selective bromination of, α,α-trehalose at C-6,6′, followed by acetylation, azide displacement, deacetylation, and reduction. Coupling of the core molecule with the protected amino acid, then deprotection and guanidinylation generated the novel α,α-trehalose derivatives. Their abilities to inhibit Tat-TAR RNA interaction in human cells were determined by a Tat-dependent HIV-1 LTR-driven CAT assays.