715-60-6

Basic information

• Product Name: 1-PENTAFLUOROPHENYL-2-THIOUREA
• Synonyms: 1-PENTAFLUOROPHENYL-2-THIOUREA;N-(PENTAFLUOROPHENYL)THIOUREA;PENTAFLUOROPHENYLTHIOUREA;N-(Pentafluorophenyl)thiourea 97%;N-(Pentafluorophenyl)thiourea97%;1-(5-Pentafluorophenyl-thiophen-2-yl)-ethanone
• CAS NO: 715-60-6
• Molecular Formula: C₇H₃F₅N₂S
• Molecular Weight: 242.17
• Mol File: 715-60-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 156-158°C
• Boiling Point: 211.6 °C at 760 mmHg
• Flash Point: 81.8 °C
• Appearance: /
• Density: 1.747 g/cm³
• Vapor Pressure: 0.181mmHg at 25°C
• Refractive Index: 1.588
• PKA: 9.85±0.70(Predicted)
• Sensitive: Stench
• CAS DataBase Reference: 1-PENTAFLUOROPHENYL-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PENTAFLUOROPHENYL-2-THIOUREA(715-60-6)
• EPA Substance Registry System: 1-PENTAFLUOROPHENYL-2-THIOUREA(715-60-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 715-60-6(Hazardous Substances Data)

Usage

General Description

1-Pentafluorophenyl-2-thiourea is a chemical compound with the molecular formula C7H4F5N3S. It is a white solid that is soluble in organic solvents and has potential applications in pharmaceutical and agrochemical industries. 1-PENTAFLUOROPHENYL-2-THIOUREA is known for its ability to form hydrogen bonds, making it a useful tool in the development of new drugs and materials. It also has potential uses in the field of catalysis, specifically in the area of cross-coupling reactions. 1-Pentafluorophenyl-2-thiourea is a promising chemical with a wide range of potential applications, and further research into its properties and uses is ongoing.

InChI:InChI=1/C7H3F5N2S/c8-1-2(9)4(11)6(14-7(13)15)5(12)3(1)10/h(H3,13,14,15)

Upstream product

• 771-60-8 2,3,4,5,6-pentafluoroaniline 

Downstream Products

• 70015-95-1 4,5,6,7-tetrafluorobenzo[d]thiazol-2-amine 

Relevant articles and documents

Disrupting the Conserved Salt Bridge in the Trimerization of Influenza A Nucleoprotein

Antiviral drug resistance in influenza infections has been a major threat to public health. To develop a broad-spectrum inhibitor of influenza to combat the problem of drug resistance, we previously identified the highly conserved E339?R416 salt bridge of the nucleoprotein trimer as a target and compound 1 as an inhibitor disrupting the salt bridge with an EC50 = 2.7 μM against influenza A (A/WSN/1933). We have further modified this compound via a structure-based approach and performed antiviral activity screening to identify compounds 29 and 30 with EC50 values of 110 and 120 nM, respectively, and without measurable host cell cytotoxicity. Compared to the clinically used neuraminidase inhibitors, these two compounds showed better activity profiles against drug-resistant influenza A strains, as well as influenza B, and improved survival of influenza-infected mice.