71501-17-2Relevant articles and documents
Metal-free visible light photoredox enables generation of carbyne equivalents via phosphonium ylide C-H activation
Das, Mrinmoy,Vu, Minh Duy,Zhang, Qi,Liu, Xue-Wei
, p. 1687 - 1691 (2019/02/14)
Carbyne, an interesting synthetic intermediate, has recently been generated from hypervalent iodine precursors via photoredox catalysis. Given the underexplored chemistry of carbyne, due to the paucity of carbyne sources, we are intrigued to discover a new source for this reactive species from classical reagents-phosphonium ylides. Our novel strategy employing phosphonium ylides in an olefin hydrocarbonation reaction features a facile approach for constructing carbon-carbon bonds through metal-free and benign reaction conditions. Moreover, the hydrocarbonation products were delivered in a highly regioselective manner.
Cross-Coupling of Amides with Alkylboranes via Nickel-Catalyzed C-N Bond Cleavage
Liu, Xiangqian,Hsiao, Chien-Chi,Guo, Lin,Rueping, Magnus
supporting information, p. 2976 - 2979 (2018/05/28)
A protocol for the nickel-catalyzed alkylation of amides was established. The use of alkylboranes as nucleophilic partners allowed the use of mild reaction conditions and compatibility of various functional groups with respect to both coupling partners. The catalytic alkylation proceeded selectively at the amides in the presence of other functional groups as well as other carboxylic acid derived moieties.
Di- and trivalent small molecule selectin inhibitors
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, (2008/06/13)
The present invention provides compounds having structure (II), and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof.
