71516-10-4Relevant articles and documents
The conversion of mixed N,O-diacylated 2-aminophenols to 2-substituted benzoxazoles
DeLuca, Mark R.,Taraporewala, Irach B.,Kerwin, Sean M.
, p. 979 - 982 (2007/10/03)
When N,O-diacylated 2-aminophenols that have different acyl substituents on nitrogen and oxygen are treated with p-toluenesulfonic acid in refluxing xylenes, mixtures of benzoxazoles are produced. The major product is the benzoxazole in which the substituent at the 2-position is derived from the acyl group on nitrogen. This product may arise from an unusual case of acid- mediated neighboring amido-group assisted hydrolysis.