71530-58-0

Basic information

• Product Name: 3-ISOPROPYL BENZENE SULFONYL CHLORIDE
• Synonyms: 3-(1-Methylethyl)benzenesulfonyl chloride;3-Isopropylbenzene-1-sulphonyl chloride;3-Isopropylbenzene-1-sulfonyl chloride
• CAS NO: 71530-58-0
• Molecular Formula: C₉H₁₁ClO₂S
• Molecular Weight: 218.70
• Mol File: 71530-58-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 290℃
• Flash Point: 129℃
• Appearance: /
• Density: 1.241
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 3-ISOPROPYL BENZENE SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ISOPROPYL BENZENE SULFONYL CHLORIDE(71530-58-0)
• EPA Substance Registry System: 3-ISOPROPYL BENZENE SULFONYL CHLORIDE(71530-58-0)

Safety Data

• Hazardous Substances Data: 71530-58-0(Hazardous Substances Data)

Usage

General Description

3-Isopropyl benzene sulfonyl chloride, also known as p-toluenesulfonyl chloride, is a chemical compound with the molecular formula C7H7ClO2S. It is often used as a reagent in organic synthesis for the introduction of the tosyl group, which is a leaving group in nucleophilic substitution reactions. 3-Isopropyl benzene sulfonyl chloride is a clear to pale yellow liquid with a strong irritating odor, and it is highly reactive with water. It is also important in the pharmaceutical industry as a protecting group for alcohols and amines. Additionally, it is used in the production of dyes, pigments, and plastics. 3-Isopropyl benzene sulfonyl chloride should be handled and stored with care as it is corrosive to skin and eyes and can cause respiratory irritation when inhaled.

Upstream product

• 98-82-8 Isopropylbenzene 

Downstream Products

• 1203588-07-1 6-[2-(((3-(1-Methylethyl)phenyl)sulphonyl)amino]-5-(trifluoro-methyl)phenyl]-5-hexynoic acid, methyl ester 
• 1203588-09-3 1-[[3-(1-Methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid 
• 1203588-10-6 1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid sodium salt 
• 1203588-11-7 1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid piperazine salt 
• 1203588-12-8 1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid tris(hydroxymethyl)aminomethane salt 
• 1203588-08-2 1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid methyl ester 
• 1203588-21-9 1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-pentanoic acid 1,1-dimethylethyl ester 
• 1272718-38-3 N-[2-iodo-4-(trifluoromethyl)-phenyl]-3-(1-methylethyl)benzenesulfonamide 
• 1272718-39-4 4-[(RS)-hydroxy[1-[[3-(1-methylethyl)phenyl]sulfonyl]-5-(trifluoro-methyl)-1H-indol-2-yl]methyl]benzoic acid, methyl ester 
• 1272718-40-7 4-[[1-[[3-(1-methylethyl)phenyl]sulfonyl]-5-(trifluoromethyl)-1H-indol-2-yl]methyl]benzoic acid, methyl ester 

Relevant articles and documents

SULFONATION OF CUMENE WITH SULFURIC AND HALOGENOSULFONIC ACIDS

The sulfonation of cumene by sulfuric and chloro- and fluorosulfonic acids in the range of 0-100 deg C under heterogenous and heterogenous-homogenous conditions gives mixtures of isomeric sulfonyl halides and/or sulfonic acids, in which the para isomer predominates (90-95percent of the total isomers at temperatures above 75 deg C and/or with the addition of the sulfonating agent to the cumene).If the reagents are mixed in the opposite order and at low temperatures (0-25 deg C), the proportion of the ortho isomer in the mixture of sulfo products increases to 20-22percent.The yield of the sulfonyl halides show an extremal relationship with temperature.The composition of the sulfonic acids and their halides formed under the conditions of a single experiment with the halogenosulfonic acids differ as a result, probably, of the nonequilibrium nature of the process and of the presence of several paths to the formation of the acid halides.