71532-40-6Relevant articles and documents
Synthesis of macrocyclic and medium-sized ring thiolactonesviathe ring expansion of lactams
Palate, Kleopas Y.,Epton, Ryan G.,Whitwood, Adrian C.,Lynam, Jason M.,Unsworth, William P.
supporting information, p. 1404 - 1411 (2021/02/27)
A side chain insertion method for the ring expansion of lactams into macrocyclic thiolactones is reported, that can also be incorporated into Successive Ring Expansion (SuRE) sequences. The reactions are less thermodynamically favourable than the analogous lactam- and lactone-forming ring expansion processes (with this notion supported by DFT data), but nonetheless, three complementary protecting group strategies have been developed to enable this challenging transformation to be achieved.
An assembly concept for the consecutive introduction of unsymmetrical disulfide bonds: Synthesis of a releasable multidrug conjugate of folic acid
Vlahov, Iontcho R.,Santhapuram, Hari Krishna R.,Wang, Yu,Kleindl, Paul J.,You, Fei,Howard, Stephen J.,Westrick, Elaine,Reddy, Joseph A.,Leamon, Christopher P.
, p. 5968 - 5972 (2008/02/09)
(Chemical Equation Presented) We describe the development of methodology which allows for the introduction of a second disulfide bond into a molecular framework with a pre-existing disulfide linker system. Compounds which contain an S-9-fluorenylmethyl-pr
Convenient Syntheses of Fluorenylmethyl-Based Side Chain Derivatives of Glutamic and Aspartic acids, Lysine and Cysteine
Albericio, F.,Nicolas, E.,Rizo, J.,Ruiz-Gayo, M.,Pedroso, E.,Giralt, E.
, p. 119 - 122 (2007/10/02)
Efficient and practical one-pot syntheses of the fluorenylmethyl-based side chain derivatives of glutamic and aspartic acids, lysine, and cysteine are described.Likewise, stability/lability of these derivatives towards solvents and reagents used in solid